چکیده: (241 مشاهده)
Background: A major contributor to hospital-acquired infections, particularly in burn units, is Pseudomonas aeruginosa (P. aeruginosa). Because this bacterium produces extended-spectrum β-lactamases (ESBLs), antibiotic resistance is a significant treatment concern. In this work, P. aeruginosa isolates from burn victims in Tabriz were examined for antibiotic resistance patterns and the presence of the blaTEM gene.
Methods: In this descriptive-cross-sectional study, 100 clinical isolates of P. aeruginosa were collected from patients hospitalized in the burn wards of Tabriz hospitals over a six-month period. Standard biochemical methods were used to identify microorganisms. Antibiotic resistance patterns were assessed by the disk diffusion technique according to clinical and laboratory standards institute protocols. Additionally, the presence of the blaTEM gene was investigated by polymerase chain reaction, and ESBL production was confirmed by the combined disk test.
Results: The highest resistance rates were observed for levofloxacin (97%) and meropenem (92%), while the lowest was for ceftazidime (69%). Furthermore, 58% (58/100) of the isolates were ESBL-positive, half of which (50%, 29/58) carried the blaTEM gene.
Conclusion: The results of this study indicated that P. aeruginosa strains in burn units of Tabriz hospitals exhibited high antibiotic resistance. Half of ESBL-positive isolates carried the blaTEM gene, highlighting the need for continuous monitoring of antibiotic resistance patterns and prudent use of antibiotics.
Methods: In this descriptive-cross-sectional study, 100 clinical isolates of P. aeruginosa were collected from patients hospitalized in the burn wards of Tabriz hospitals over a six-month period. Standard biochemical methods were used to identify microorganisms. Antibiotic resistance patterns were assessed by the disk diffusion technique according to clinical and laboratory standards institute protocols. Additionally, the presence of the blaTEM gene was investigated by polymerase chain reaction, and ESBL production was confirmed by the combined disk test.
Results: The highest resistance rates were observed for levofloxacin (97%) and meropenem (92%), while the lowest was for ceftazidime (69%). Furthermore, 58% (58/100) of the isolates were ESBL-positive, half of which (50%, 29/58) carried the blaTEM gene.
Conclusion: The results of this study indicated that P. aeruginosa strains in burn units of Tabriz hospitals exhibited high antibiotic resistance. Half of ESBL-positive isolates carried the blaTEM gene, highlighting the need for continuous monitoring of antibiotic resistance patterns and prudent use of antibiotics.
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