Volume 9, Issue 2 (6-2021)                   Jorjani Biomed J 2021, 9(2): 45-54 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Yahyaei B, Varmazyar S. Investigation of the Effects of Methylphenidate and Endurance Exercise on Structural Changes in Brain Tissue of Male Rats with Hyperactivity. Jorjani Biomed J. 2021; 9 (2) :45-54
URL: http://goums.ac.ir/jorjanijournal/article-1-818-en.html
1- Department of Medical Sciences, Shahrood Branch, Islamic Azad University, Shahrood, Iran , behroozyahyaei@iau-shahrood.ac.ir
2- Department of Medical Sciences, Biological Nanoparticles in Medicine Research center, Shahrood Branch, Islamic Azad University, Shahrood, Iran
Abstract:   (732 Views)
Background and Objective: This study was conducted aimed to compare effects of Methylphenidate and endurance exercise on histopathological changes in brain tissue of male Wistar rats with attention deficit hyperactivity disorder (ADHD).
Material and Methods: In this study, 33 rats were divided into a control group (5 rats) and 4 experimental groups (28 rats) and 10 mg/kg of L-NAME (L-Arginine Methyl Ester) was injected peritoneally for 8 weeks for 6 days a week. Rats that tested positive for open test were used. Balance and motor coordination tests were taken after 8 weeks of training using Beam Walking or Balance Test. The drug group was given 1 mg per kg of Methylphenidate orally. The rats in the exercise group trained 30 minutes a day and 7 days a week for 4 weeks. Open Field Test was used to diagnose hyperactivity. 5-band treadmill was used for doing endurance exercise.
Results: The results of the present study show that the effect of exercise on reducing histopathological changes in brain tissue in neonatal rats with ADHD is present. Therefore, it can be stated that exercise can be an alternative to the drugs such as methylphenidate.
Conclusion: According to the studyresults, the effect of exercise alone to methylphenidate is greater on brain tissue changes. Although the drug has been more effective on improving some variables such as changes in gray matter, it has not reduced neuronal changes, congestion and inflammation not seen in the exercise group. Also, the study results of simultaneous drug use and exercise are satisfactory.
Full-Text [PDF 645 kb]   (162 Downloads) |   |   Full-Text (HTML)  (85 Views)  
Exercise can be an alternative to the use of drugs such as methylphenidateIt is possible to emphasize the need for endurance exercise to reduce blood pressure and treat hyperactivity.
Type of Article: Original article | Subject: Basic Medical Sciences
Received: 2021/04/3 | Accepted: 2021/06/1 | Published: 2021/06/20

1. Sibley MH, Mitchell JT, Becker SP. Method of adult diagnosis influences estimated persistence of childhood ADHD: a systematic review of longitudinal studies. Lancet Psychiatry. 2016;3(12):1157-65. [view at publisher] [DOI] [Google Scholar]
2. Biederman J. Attention-deficit/hyperactivity disorder: a selective overview. Biological psychiatry. 2005;57(11):1215-20. [view at publisher] [DOI] [Google Scholar]
3. Shadmehri S, Ahmadi M, Abbassi-Daloii A, Ziaolhagh SJ, Yahyaei B. Motor coordination and structural changes of hippocampus tissue in response to eight weeks of aerobic training and Methylphenidate consumption in hyperactive rats. Feyz Journal of Kashan University of Medical Sciences. 2018;22(5):458-68. [view at publisher] [Google Scholar]
4. JamshidiTari N, Fazelipoor S, LooieMonfared A, Tootian Z. Study of histometric and histopathologic changes and biochemical functioning of liver in mice Balb/C treated with methylphenidate. Medical Science Journal of Islamic Azad Univesity-Tehran Medical Branch. 2016;26(3):135-41. [view at publisher] [Google Scholar]
5. Salviano LHMS, Linhares MI, de Lima KA, de Souza AG, Lima DB, Jorge ARC, et al. Study of the safety of methylphenidate: Focus on nephrotoxicity aspects. Life sciences. 2015;141:137-42. [view at publisher] [DOI] [Google Scholar]
6. Lotfi M, Nouri A, Karimi A, Pilehvarian A. The effects of methamphetamine on the development of the testes in immature male rats. SSU_Journals. 2016;24(3):222-31. [Google Scholar]
7. Ramasamy R, Dadhich P, Dhingra A, Lipshultz L. Case Report: Testicular failure possibly associated with chronic use of methylphenidate. F1000Research. 2014;3. [view at publisher] [DOI] [Google Scholar]
8. Montagnini BG, Silva LS, dos Santos AH, Anselmo-Franci JA, Fernandes GSA, MesquitaSdFP, et al. Effects of repeated administration of methylphenidate on reproductive parameters in male rats. [view at publisher] [Google Scholar]
9. Kim H, Heo H-I, Kim D-H, Ko I-G, Lee S-S, Kim S-E, et al. Treadmill exercise and methylphenidate ameliorate symptoms of attention deficit/hyperactivity disorder through enhancing dopamine synthesis and brain-derived neurotrophic factor expression in spontaneous hypertensive rats. Neuroscience letters. 2011;504(1):35-9. [view at publisher] [DOI] [Google Scholar]
10. Cho HS, Baek DJ, Baek SS. Effect of exercise on hyperactivity, impulsivity and dopamine D2 receptor expression in the substantia nigra and striatum of spontaneous hypertensive rats. Journal of exercise nutrition & biochemistry. 2014;18(4):379. [view at publisher] [DOI] [Google Scholar]
11. Bahcelioglu M, Gozil R, Take G, Elmas C, Oktem H, Kadioglu D, et al. Dose-related immunohistochemical and ultrastructural changes after oral methylphenidate administration in cerebrum and cerebellum of the rat. The World Journal of Biological Psychiatry. 2009;10(4-2):531-43. [view at publisher] [DOI] [Google Scholar]
12. Biederman J, Spencer T, Wilens T. Evidence-based pharmacotherapy for attention-deficit hyperactivity disorder. International Journal of Neuropsychopharmacology. 2004;7(1):77-97 [view at publisher] [DOI] [Google Scholar]
13. Kopincová J, Púzserová A, Bernátová I. L-NAME in the cardiovascular system - nitric oxide synthase activator? Pharmacol Rep. 2012;64(3):511-20. [DOI]
14. Yahyaei B, Nouri M, Ramezani M. The Effects of Anabolic Steroids Boldenone with Eight Weeks Aerobic Exercise on Histopathological Changes in Cerebellum Male Wistar Rats. Journal of Sabzevar University of Medical Sciences, 2019;25(6):885-894. [view at publisher] [Google Scholar]

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2021 CC BY-NC 4.0 | Jorjani Biomedicine Journal

Designed & Developed by : Yektaweb