Volume 7, Issue 1 (3-2019)
Jorjani Biomed J 2019, 7(1): 39-50 |
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Ahmed V A, Ahmed B S. Reduction of Serum Vitamin B12 Levels among the Female Patients with Breast Cancer (Case Study: Sulaimania city- Iraq). Jorjani Biomed J 2019; 7 (1) :39-50
URL: http://goums.ac.ir/jorjanijournal/article-1-653-en.html
URL: http://goums.ac.ir/jorjanijournal/article-1-653-en.html
1- Department of Clinical Biochemistry, College of Pharmacy, University of Sulamania, Iraq
2- Department of Clinical Biochemistry, College of Pharmacy, University of Sulamania, Iraq , basima.ahmed@univsul.edu.iq
2- Department of Clinical Biochemistry, College of Pharmacy, University of Sulamania, Iraq , basima.ahmed@univsul.edu.iq
Abstract: (5928 Views)
Background and objectives: Breast carcinoma is one of the most common malignant diseases among women worldwide. In Iraq there are noticeable elevation in incidence rates and prevalence of advanced stages of breast cancer. Cobalamin (vitamin B12) is essential micronutrient involved in one carbon metabolism and DNA methylation, which affects cancer. All of these may be change in breast cancer. The present work was designed to estimate and compare serum vitamin B12 among female breast cancer patients (60 ones) and healthy control subjects (60 ones) in Sulaimania city.
Methods: This is a case-control study conducted on sixty cases of newly diagnosed women with breast cancer, the control group include sixty healthy women. Serum vitamin B12 levels were estimated by electrochemiluminescence immunoassay (Elecsys) method. Data was analyzed using the software SPSS (Ver. 22) including frequency and percentage for categorical variables. Pearson chi-square test was used for analysis of all categorical variables.
Results: In this study we found that serum vitamin B12 levels were significantly (p=0.01) lower in breast cancer patients as compared to healthy control subject. There was no association between serum vitamin B12 levels with estrogen, progesterone, and HER2 receptor.
Conclusion: Given the results, it can be concluded that serum vitamin B12 is consistently lower among breast cancer patients. There was no association between serum vitamin B12 levels and hormones receptors status, indicating clinical implications for the interpretation of serum vitamin B12 levels. Therefore, it should be taken into consideration by physicians and cancer specialists.
Methods: This is a case-control study conducted on sixty cases of newly diagnosed women with breast cancer, the control group include sixty healthy women. Serum vitamin B12 levels were estimated by electrochemiluminescence immunoassay (Elecsys) method. Data was analyzed using the software SPSS (Ver. 22) including frequency and percentage for categorical variables. Pearson chi-square test was used for analysis of all categorical variables.
Results: In this study we found that serum vitamin B12 levels were significantly (p=0.01) lower in breast cancer patients as compared to healthy control subject. There was no association between serum vitamin B12 levels with estrogen, progesterone, and HER2 receptor.
Conclusion: Given the results, it can be concluded that serum vitamin B12 is consistently lower among breast cancer patients. There was no association between serum vitamin B12 levels and hormones receptors status, indicating clinical implications for the interpretation of serum vitamin B12 levels. Therefore, it should be taken into consideration by physicians and cancer specialists.
Keywords: vitamin B12
Type of Article: Original article |
Subject:
Basic Medical Sciences
Received: 2019/01/29 | Accepted: 2019/03/27 | Published: 2019/07/30
Received: 2019/01/29 | Accepted: 2019/03/27 | Published: 2019/07/30
References
1. Siegel RL, Miller KD, Fedewa SA, Ahnen, DJ et al. Colorectal Cancer Statistics , 2017. CA Cancer J Clin. 2017;67(3):177-93. [DOI] [Google Scholar]
2. Alwan NA. Breast cancer : demographic characteristics and clinico-pathological presentation of patients in Iraq. East Mediterr Heal J. 2010;16(11):1159-64. [DOI] [Google Scholar]
3. Iraqi Cancer Board. Results of the Iraq Cancer Registry 2012. Baghdad, Iraq; 2015.
4. Mason JB. Biomarkers of Nutrient Exposure and Status in One-Carbon (Methyl) Metabolism. J Nutr. 2003 Mar 1;133(3):941S-947S. [DOI] [Google Scholar]
5. Yamada K. Cobalt: Its Role in Health and Disease. In: Metal ions in life sciences. 2013 . p. 295-320. [DOI] [Google Scholar]
6. Miller A, Korem M, Almog R et al. Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. J Neurol Sci. 2005 Jun 15;233(1-2):93-7. [DOI] [Google Scholar]
7. Nielsen MJ RM, Andersen CB, Nexo E, Moestrup SK. Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway. Nat Rev Gastroenterol Hepatol. 2012;9(6):345-54. [DOI] [Google Scholar]
8. R C. Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II. Am J Clin Nutr. 2011;94(1):348-58. [DOI] [Google Scholar]
9. Hultdin J, Guelpen B Van, Bergh A. Plasma folate , vitamin B12 , and homocysteine and prostate cancer risk : A prospective study. Int J Cancer. 2005;113:819-24. [DOI] [Google Scholar]
10. Dowd P, Shapiro M, Kang K. Mechanism of action of vitamin B12. J Am Chem Soc. 1975 Aug;97(16):4754-7. [DOI]
11. Cooper AJ. Biochemistry of Sulfur-Containing Amino Acids. Annu Rev Biochem. 1983 Jun;52(1):187-222. [DOI] [Google Scholar]
12. Mason JB LT. Folate: effects on carcinogenesis and the potential for cancer chemoprevention. Oncol . 1996 Nov;10(11):1727-36, 1742-3; discussion 1743-4. [Google Scholar]
13. Eto I KC. Role of vitamin B12 and folate deficiencies in carcinogenesis. Adv Exp Med Biol. 1986;206:313-30. [DOI] [Google Scholar]
14. Arendt JF PL, Nexo E, Sørensen HT. Elevated plasma vitamin B12 levels as a marker for cancer: a population-based cohort study. J Natl Cancer Inst. 2013;105(23):1799-805. [DOI] [Google Scholar]
15. Chang SC GB, Mu L, et al. . Plasma folate, vitamin B12, and homocysteine and cancers of the esophagus, stomach, and liver in a Chinese population. Nutr Cancer. 2015;67(2):212-23. [DOI] [Google Scholar]
16. Zhang SM, Willett WC, Selhub J, Hunter DJ, Giovannucci EL, Holmes MD, et al. Plasma Folate, Vitamin B6, Vitamin B12, Homocysteine, and Risk of Breast Cancer. JNCI J Natl Cancer Inst. 2003 Mar 5;95(5):373-80. [DOI] [Google Scholar]
17. Kana W, Helzlsouer KJ, Comstock GW, Hoffman SC, Nadeau MR and SJ. A prospective study on folate, B12, and pyridoxal 5'-phosphate (B6) and breast cancer. Cancer Epidemiol Biomarkers Prev. 1999;8:209-17. [Google Scholar]
18. Lin J, Lee IM, Cook NR, Selhub J, Manson JE et al. Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women. Am J Clin Nutr. 2008 Mar 1;87(3):734-43. [DOI] [Google Scholar]
19. Matejcic M, Batlle JD, Ricci C, Biessy C, Perrier F et al. Biomarkers of folate and vitamin B12 and breast cancer risk : report from the EPIC cohort. Int J Cancer Biomarkers. 2017;140:1246-59. [DOI] [Google Scholar]
20. Luczak MW JP. The role of DNA methylation in cancer development. Folia Histochem Cytobiol. 2006;44(3):143-54. [Google Scholar]
21. Dizik M, Christman JK WE. Alterations in expression and methylation of specific gene in livers of rats fed a cancer promoting methyl-deficient diet. Carcinogenesis. 1991 Jul;12(7):1307-12. [DOI] [Google Scholar]
22. Wu W, Kang S, Zhang D. Association of vitamin B 6, vitamin B 12 and methionine with risk of breast cancer: A dose-response meta-analysis. Br J Cancer. 2013;109(7):1926-44. [DOI] [Google Scholar]
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