دوره 6، شماره 3 - ( پاییز 1397 )                   جلد 6 شماره 3 صفحات 40-47 | برگشت به فهرست نسخه ها


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Ghovanjzadeh S, Bazzazi H, Yazdani Y. Lack of Association between PTPN22 (+1858 C>T) rs2476601 polymorphism and susceptibility to rheumatoid arthritis (RA) in Northeast of Iran. Jorjani Biomed J. 2018; 6 (3) :40-47
URL: http://goums.ac.ir/jorjanijournal/article-1-622-fa.html
Lack of Association between PTPN22 (+1858 C>T) rs2476601 polymorphism and susceptibility to rheumatoid arthritis (RA) in Northeast of Iran. فصلنامه علمی پژوهشی زیست پزشکی جرجانی. 1397; 6 (3) :40-47

URL: http://goums.ac.ir/jorjanijournal/article-1-622-fa.html


چکیده:   (843 مشاهده)
Background and objectives: Rheumatoid arthritis (RA) is an autoimmune disease with a complex genetic background. The protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a lymphoid specific protein tyrosine phosphatase which is involved in negative regulation of T cell response. Several studies have assessed the association between PTPN22 single nucleotide polymorphisms (SNPs) with RA susceptibility. Here, we aimed to assess the association of PTPN22 (1858 C>T) variant with the susceptibility to RA in northeast of Iran.
Methods: A total of 127 RA patients and 119 age- and sex- matched healthy donors were enrolled. The polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) technique (PCR-RFLP) was applied to detect PTPN22 (1858 C>T) SNP. SPSS 22.0 software was used to analyze data using relevant statistical tests.
Results: Comparison of allele and genotype frequencies of PTPN22 (1858 C>T) SNP in RA patients and healthy donors revealed no significant association with RA susceptibility.
Conclusion: The present study suggests that the PTPN22 (1858 C>T) genetic variants are not associated with RA susceptibility and disease activity. While this is the first report from northeast of Iran, further studies are needed to confirm these findings
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نوع مقاله: تحقیقی | موضوع مقاله: علوم مولکولی
دریافت: ۱۳۹۷/۵/۲۴ | ویرایش نهایی: ۱۳۹۸/۱۱/۷ | پذیرش: ۱۳۹۷/۷/۱۴

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