Volume 6, Issue 3 (Autumn 2018)                   Jorjani Biomed J 2018, 6(3): 41-50 | Back to browse issues page

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Ghovanjzadeh S, Bazzazi* H, Yazdani Y. Lack of Association between PTPN22 (+1858 C>T) rs2476601 polymorphism and susceptibility to rheumatoid arthritis (RA) in Northeast of Iran. Jorjani Biomed J. 2018; 6 (3) :41-50
URL: http://goums.ac.ir/jorjanijournal/article-1-622-en.html
1- Department of Biology, Gorgan Branch, Islamic Azad University, Gorgan, Iran
2- Department of Medical Laboratory Sciences, Gorgan Branch, Islamic Azad University, Gorgan, Iran
3- Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Abstract:   (74 Views)
Background: Rheumatoid arthritis (RA) is an autoimmune disease with a complex genetic background. The protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a lymphoid specific protein tyrosine phosphatase which is involved in negative regulation of T cell response. Several studies have assessed the association between PTPN22 single nucleotide polymorphisms (SNPs) with RA susceptibility. Here, we aimed to assess the association of PTPN22 (1858 C>T) variant with the susceptibility to RA in northeast of Iran.
Methods: A total of 127 RA patients and 119 age- and sex- matched healthy donors were enrolled. The polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) technique (PCR-RFLP) was applied to detect PTPN22 (1858 C>T) SNP. SPSS 22.0 software was used to analyze data using relevant statistical tests.
Results: Comparison of allele and genotype frequencies of PTPN22 (1858 C>T) SNP in RA patients and healthy donors revealed no significant association with RA susceptibility.
Conclusion: The present study suggests that the PTPN22 (1858 C>T) genetic variants are not associated with RA susceptibility and disease activity. While this is the first report from northeast of Iran, further studies are needed to confirm these findings
Type of Article: Original article | Subject: Basic Medical Sciences
Received: 2019/01/2 | Revised: 2019/01/6 | Accepted: 2019/01/2 | Published: 2019/01/2

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