Volume 6, Issue 3 (Autumn 2018)                   Jorjani Biomed J 2018, 6(3): 40-47 | Back to browse issues page

DOI: 10.29252/jorjanibiomedj.6.3.40


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1- Department of Biology, Gorgan Branch, Islamic Azad University, Gorgan, Iran
2- Department of Medical Laboratory Sciences, Gorgan Branch, Islamic Azad University, Gorgan, Iran , hadi.bazzazi@gmail.com
3- Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Abstract:   (842 Views)
Background and objectives: Rheumatoid arthritis (RA) is an autoimmune disease with a complex genetic background. The protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a lymphoid specific protein tyrosine phosphatase which is involved in negative regulation of T cell response. Several studies have assessed the association between PTPN22 single nucleotide polymorphisms (SNPs) with RA susceptibility. Here, we aimed to assess the association of PTPN22 (1858 C>T) variant with the susceptibility to RA in northeast of Iran.
Methods: A total of 127 RA patients and 119 age- and sex- matched healthy donors were enrolled. The polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) technique (PCR-RFLP) was applied to detect PTPN22 (1858 C>T) SNP. SPSS 22.0 software was used to analyze data using relevant statistical tests.
Results: Comparison of allele and genotype frequencies of PTPN22 (1858 C>T) SNP in RA patients and healthy donors revealed no significant association with RA susceptibility.
Conclusion: The present study suggests that the PTPN22 (1858 C>T) genetic variants are not associated with RA susceptibility and disease activity. While this is the first report from northeast of Iran, further studies are needed to confirm these findings
Full-Text [PDF 339 kb]   (274 Downloads)    
Type of Article: Original article | Subject: Molecular Sciences
Received: 2018/08/15 | Revised: 2020/01/27 | Accepted: 2018/10/6

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