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:: Volume 3, Number 1 (Spring & Summer 2015 2015) ::
Hakim Jorjani J 2015, 3(1): 3-15 Back to browse issues page
Study the Molecular Association between a Deletion Mutation in CHEK2 gene (5395 bp) and Breast Cancer
Manijeh Jalilvand, Reza Najafipoor, Mohammad Shekari , Mana Oloomi, Safar Ali Alizadeh, Abdolazim Nejatizadeh
Department of Medical Genetics Hormozgan University of Medical Sciences, Bandar-e-Abbas, Iran
Abstract:   (2199 Views)

Background & Objectives: Breast cancer is the most common cancer among women and the second most common cause of cancer death. Genetic factors play an important role in the development of breast cancer. Among these genetic factors, CHEk2 (checkpoint kinase 2) gene, as a tumor suppressor gene, plays a critical role in DNA repair. Germline mutations in CEHK2 result in the loss of this feature. One of the mutations in CHEK2 gene is a 5395 bp deletion mutation which has been associated with the increasing risk of Breast Cancer in some populations in the world.  In the present study, we investigated the association between a 5395 bp deletion mutation in CHEK2 gene and the risk of Breast Cancer in the women of an Iranian population.

Methods: Pathologic information of 38 cases under the age of 45 and 62 cases over the age of 45 referring to surgery ward of Milad Hospital in Tehran were extracted. 100 healthy controls were included in the study as well. After obtaining informed consent, 5 mL whole blood was taken DNA was successfully isolated. Multiplex PCR was used to investigate the association between a 5395bp deletion mutation in CHEK2 gene and increasing risk of Breast Cancer among patients.

Results: The 5395bp deletion mutation in CHEK2 gene was not found in any of the participating groups of patients or heathy controls.

Conclusion: The present study revealed that there is no significant relation between increasing the risk of Breast Cancer and bearing large deletion mutation in exon 9 and exon 10 of CHECK2 gene.

Keywords: Breast Cancer, CHEK2, 5395 bp Deletion Mutation
Full-Text [PDF 701 kb]   (830 Downloads)    
Type of Study: Original paper | Subject: General
Received: 2015/10/8 | Accepted: 2015/10/8 | Published: 2015/10/8
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Jalilvand M, Najafipoor R, Shekari M, Oloomi M, Alizadeh S A, Nejatizadeh A. Study the Molecular Association between a Deletion Mutation in CHEK2 gene (5395 bp) and Breast Cancer. Hakim Jorjani J. 2015; 3 (1) :3-15
URL: http://goums.ac.ir/jorjanijournal/article-1-335-en.html
Volume 3, Number 1 (Spring & Summer 2015 2015) Back to browse issues page
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