Volume 9, Issue 1 (3-2021)
Jorjani Biomed J 2021, 9(1): 55-68 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Rafiei S, Ravasi A A, Gaeini A A. The Effect of Eight-week Swimming Exercise and Gallic Acid on Hippocampal BDNF and Oxidative Stress Parameters in Trimethyltin Induced Cognitive deficits. Jorjani Biomed J 2021; 9 (1) :55-68
URL: http://goums.ac.ir/jorjanijournal/article-1-801-en.html
URL: http://goums.ac.ir/jorjanijournal/article-1-801-en.html
1- Department of Exercise Physiology, Kish International Campus, University of Tehran, Kish, Iran , samanerafie6360@gmail.com
2- Department of Exercise Physiology, University of Tehran, Tehran, Iran
2- Department of Exercise Physiology, University of Tehran, Tehran, Iran
Abstract: (6571 Views)
Background and Objective: Trimethyltin (TMT) is an organotin neurotoxin which causes cognitive disorders by the induction of selective damage in hippocampus. The present study evaluates the effect of 8-week swimming exercise (EX) and Gallic acid (GA) for working and avoidance memory, hippocampal oxidative stress indices and brain neurotrophic factor expression (BDNF) in rats after TMT intoxication.
Material and Methods: In this experimental study, 40 Wistar mature male rats were randomly put in 5 groups of control, TMT+NS, TMT+GA200, TMT+EX, TMT+GA200+EX. 24 hours after TMT intoxication (8mg/kg), 8 weeks of swimming exercise (3 sessions per week), and treatment with GA (200mg/kg) were done. Then, the evaluation of working and passive avoidance memory was performed respectively by the use of Y maze and shuttle box. Hippocampal level of catalase (CAT), total antioxidant capacity (TAC) and BDNF were done by ELISA method, and content of malondialdehyde (MDA) was performed by thiobarbituric acid (MDA). Statistical differences between groups were analyzed by two-way ANOVA and Bonferroni post hoc test.
Results: The significant decrease in the percentage of alteration behaviors, latency time to the dark room, along with BDNF, CAT, TAC and increase of MDA were seen in TMT+NS group compared to control group (p<0.01). Swimming exercise in the interaction with GA ameliorates working and avoidance memory by increasing BDNF, CAT, TAC, and decrease of MDA compared to TMT+NS group (p<0.05).
Conclusion: It seems that swimming exercise and GA administration improves cognitive symptoms following TMT intoxication simultaneously by decreasing oxidative stress and increasing BDNF expression.
Material and Methods: In this experimental study, 40 Wistar mature male rats were randomly put in 5 groups of control, TMT+NS, TMT+GA200, TMT+EX, TMT+GA200+EX. 24 hours after TMT intoxication (8mg/kg), 8 weeks of swimming exercise (3 sessions per week), and treatment with GA (200mg/kg) were done. Then, the evaluation of working and passive avoidance memory was performed respectively by the use of Y maze and shuttle box. Hippocampal level of catalase (CAT), total antioxidant capacity (TAC) and BDNF were done by ELISA method, and content of malondialdehyde (MDA) was performed by thiobarbituric acid (MDA). Statistical differences between groups were analyzed by two-way ANOVA and Bonferroni post hoc test.
Results: The significant decrease in the percentage of alteration behaviors, latency time to the dark room, along with BDNF, CAT, TAC and increase of MDA were seen in TMT+NS group compared to control group (p<0.01). Swimming exercise in the interaction with GA ameliorates working and avoidance memory by increasing BDNF, CAT, TAC, and decrease of MDA compared to TMT+NS group (p<0.05).
Conclusion: It seems that swimming exercise and GA administration improves cognitive symptoms following TMT intoxication simultaneously by decreasing oxidative stress and increasing BDNF expression.
Keywords: Swimming [MeSH], Trimethyltin Compounds [MeSH], Gallic acid [MeSH], Oxidative stress [MeSH], Brain-Derived Neurotrophic Factor [MeSH]
Type of Article: Original article |
Subject:
Basic Medical Sciences
Received: 2021/02/16 | Accepted: 2021/03/2 | Published: 2021/03/30
Received: 2021/02/16 | Accepted: 2021/03/2 | Published: 2021/03/30
References
1. Ferraz da Silva I, Freitas-Lima LC, Graceli JB, Rodrigues LCM. Organotins in Neuronal Damage, Brain Function, and Behavior: A Short Review. Front Endocrinol (Lausanne). 2018; 8:366. [view at publisher] [DOI] [Google Scholar]
2. Shintani N, Ogita K, Hashimoto H, Baba A. Recent studies on the trimethyltin actions in central nervous systems. Yakugaku Zasshi. 2007; 127(3):451-61. [view at publisher] [DOI] [Google Scholar]
3. Corvino V, Marchese E, Michetti F, Geloso MC. Neuroprotective strategies in hippocampal neurodegeneration induced by the neurotoxicant trimethyltin. Neurochem Res. 2013; 38(2):240-53. [view at publisher] [DOI] [Google Scholar]
4. Ceccariglia S, Alvino A, Del Fà A, Parolini O, Michetti F, Gangitano C. Autophagy is Activated In Vivo during Trimethyltin-Induced Apoptotic Neurodegeneration: A Study in the Rat Hippocampus. Int J Mol Sci. 2019; 21(1). pii: E175. [view at publisher] [DOI] [Google Scholar]
5. Lee S, Yang M, Kim J, Kang S, Kim J, Kim JC, et al. Trimethyltin-induced hippocampal neurodegeneration: A mechanism-based review. Brain Res Bull. 2016; 125:187-99. [view at publisher] [DOI] [Google Scholar]
6. Baciak L, Gasparova Z, Liptaj T, Juranek I. In vivo magnetic resonance approach to trimethyltin induced neurodegeneration in rats. Brain Res. 2017; 1673:111-6. [view at publisher] [DOI] [Google Scholar]
7. Billingsley ML, Yun J, Reese BE, Davidson CE, Buck-Koehntop BA, Veglia G. Functional and structural properties of stannin: roles in cellular growth, selective toxicity, and mitochondrial responses to injury. J Cell Biochem. 2006; 98(2):243-50. [view at publisher] [DOI] [Google Scholar]
8. Geloso MC, Corvino V, Michetti F. Trimethyltin-induced hippocampal degeneration as a tool to investigate neurodegenerative processes. Neurochemistry Int. 2011; 58(7): 729-38. [view at publisher] [DOI] [Google Scholar]
9. Lee S, Yang M, Kim J, Son Y, Kim J, Kang S, Ahn W, Kim SH, Kim JC, Shin T, Wang H, Moon C. Involvement of BDNF/ERK signaling in spontaneous recovery from trimethyltin-induced hippocampal neurotoxicity in mice. Brain Res Bull. 2016; 121:48-58. [view at publisher] [DOI] [Google Scholar]
10. Choi SJ, Oh SS, Kim CR, Kwon YK, Suh SH, Kim JK, Park GG, Son SY, Shin DH. Perilla frutescens Extract Ameliorates Acetylcholinesterase and Trimethyltin Chloride-Induced Neurotoxicity. J Med Food. 2016; 19(3):281-9. [view at publisher] [DOI] [Google Scholar]
11. Chen X, Zhang Y, Wang X, Meng X. Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases. Biomed Pharmacother. 2021; 133:110985. [view at publisher] [DOI] [Google Scholar]
12. Choubey S, Goyal S, Varughese LR, Kumar V. Probing Gallic Acid for Its Broad Spectrum Applications. Mini Rev Med Chem. 2018; 18(15):1283-93. [view at publisher] [DOI] [Google Scholar]
13. Javaid N, Shah MA, Rasul A, Chauhdary Z, Saleem U, Khan H, et al. Neuroprotective Effects of Ellagic Acid in Alzheimer's Disease: Focus on Underlying Molecular Mechanisms of Therapeutic Potential. Curr Pharm Des. 2020 Nov 12. [view at publisher] [DOI] [Google Scholar]
14. Firth J, Stubbs B, Vancampfort D, Schuch F, Lagopoulos J, Rosenbaum S, Ward PB. Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis. Neuroimage. 2018; 166:230-238. [view at publisher] [DOI] [Google Scholar]
15. Herting MM, Chu X. Exercise, cognition, and the adolescent brain. Birth Defects Res. 2017; 109(20):1672-1679. [view at publisher] [DOI] [Google Scholar]
16. Marques-Aleixo I, Beleza J, Sampaio A, Stevanović J, Coxito P, Gonçalves I, et al. Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases. Antioxid Redox Signal. 2021;34(8):674-693. [view at publisher] [DOI] [Google Scholar]
17. Rafiei S, Bazyar Y, Edalatmanesh MA. Effect of Gallic Acid and Endurance Exercise Training on BDNF in a Model of Hippocampal Degeneration. Shefaye Khatam. 2016; 4(1):1-6. [In Persian] [DOI] [Google Scholar]
18. Rafiei S, Edalatmanesh MA. The effect of swimming training, Gallic acid and high-fat diet on the serum levels of sex hormones in rats with polycystic ovary syndrome. Feyz. 2018; 22 (6): 564-572. [In Persian] [view at publisher] [Google Scholar]
19. Delaviz M, Edalatmanesh MA.The effect of trans-Cinnamic acid on prenatal seizures induced cognitive deficits. J Neyshabur Univ Med Sci. 2019;7(3):104-18. [In Persian] [view at publisher] [Google Scholar]
20. Esfandiari Z, Edalatmanesh MA. Neuroprotective Effect of Gallic Acid on Memory Deficit and Content of BDNF in Brain Entorhinal Cortex of Rat's Offspring in Uteroplacental Insufficiency Model. J Shahid Sadoughi Univ. 2020; 27(9):1864-1876. [In Persian] [view at publisher] [DOI] [Google Scholar]
21. Sadoughi SD, Edalatmanesh MA, Rahbarian R. The Effect of Curcumin on Pituitary-Gonadal Axis, DNA Oxidative Damage and Antioxidant Enzymes Activity of Testicular Tissue in Male Diabetic Rats. J Fasa Univ Med Sci. 2018; 7(4):511-20. [In Persian] [view at publisher] [Google Scholar]
22. Edalatmanesh MA, Shahsavan S, Rafiei S, Khodabandeh H. The Effect of Gallic Acid on Depression Symptoms, Oxidative Stress Markers and Inflammatory Cytokines in Rats' Hippocampus After TMT Intoxication: An Experimental Study. J Rafsanjan Univ Med Sci. 2018; 17 (9) :815-828. [In Persian] [view at publisher] [Google Scholar]
23. Urbina-Varela R, Soto-Espinoza MI, Vargas R, Quiñones L, Del Campo A. Influence of BDNF Genetic Polymorphisms in the Pathophysiology of Aging-related Diseases. Aging Dis. 2020; 11(6):1513-1526. [view at publisher] [DOI] [Google Scholar]
24. Taheri-Chadorneshin H, Cheragh-Birjandi S, Ramezani S, Abtahi-Eivary SH.Comparing sprint and endurance training on anxiety, depression and its relation with brain- derived neurotrophic factor in rats. Behav Brain Res. 2017; 329:1-5. [view at publisher] [DOI] [Google Scholar]
25. Dabidi RV, Hosseinzadeh S, Mahjoub S, Hosseinzadeh M, Myers J. Endurance exercise training and diferuloyl methane supplement: changes in neurotrophic factor and oxidative stress induced by lead in rat brain. Biol Sport. 2013; 30(1):41-6. [view at publisher] [DOI] [Google Scholar]
26. Sasi M, Vignoli B, Canossa M, Blum R. Neurobiology of local and intercellular BDNF signaling. Pflugers Arch. 2017; 469(5-6):593-610. [view at publisher] [DOI] [Google Scholar]
27. Håkansson K, Ledreux A, Daffner K, Terjestam Y, Bergman P, Carlsson R, et al. BDNF Responses in Healthy Older Persons to 35 Minutes of Physical Exercise, Cognitive Training, and Mindfulness: Associations with Working Memory Function. J Alzheimers Dis. 2017; 55(2):645-657. [view at publisher] [DOI] [Google Scholar]
28. Li J, Liu Y, Liu B, Li F, Hu J, Wang Q, et al. Mechanisms of Aerobic Exercise Upregulating the Expression of Hippocampal Synaptic Plasticity-Associated Proteins in Diabetic Rats. Neural Plast. 2019; 2019:7920540. [view at publisher] [DOI] [Google Scholar]
29. Irandoust, K., Taheri, M., Sadeghi, A. The Effect of Exercise (Swimming and Running) on Motor Function, learning and Spatial Memory in Elder Male Wistar Rats. J Motor Learning Mov. 2014; 6(2): 259-270. [view at publisher] [Google Scholar]
30. Ribeiro JKC, Nascimento TV, Agostinho AG, Freitas RM, Santos LHP, Machado LMQ, et al. Evaluation of Hypoglycemic Therapy Through Physical Exercise in n5STZ-Induced Diabetes Rats. Diabetes Metab Syndr Obes. 2020; 13:991-1004. [view at publisher] [DOI] [Google Scholar]
31. Akbari F, Moghadasi M, Farsi S, Edalatmanesh MA. The Effect of Eight Weeks Moderate-Intensity Endurance Training with Saffron Intake on Memory and Learning in Rats with Trimethytin Model of Alzheimer's Disease. J Applied Exe Physiol. 2019; 15:115-128. [In Persian] [view at publisher] [Google Scholar]
32. Daglia M, Di Lorenzo A, Nabavi SF, Talas ZS, Nabavi SM. Polyphenols: well beyond the antioxidant capacity: gallic acid and related compounds as neuroprotective agents: you are what you eat! Curr Pharm Biotechnol. 2014; 15(4):362-72. [view at publisher] [DOI] [Google Scholar]
33. Baziyar Y, Edalatmanesh MA, Hosseini SA, Zar A. The Effects of Endurance Training and Gallic Acid on BDNF and TNF-a in Male Rats with Alzheimer. Int J Appl Exerc Physiol. 2017; 5(4):45-54. [Google Scholar]
34. Mirshekar MA, Sarkaki A, Farbood Y, Gharib Naseri MK, Badavi M, Mansouri MT, Haghparast A. Neuroprotective effects of gallic acid in a rat model of traumatic brain injury: behavioral, electrophysiological, and molecular studies. Iran J Basic Med Sci. 2018; 21(10):1056-1063. [view at publisher] [Google Scholar]
35. Mirshekari Jahangiri H, Sarkaki A, Farbood Y, Dianat M, Goudarzi G. Gallic acid affects blood-brain barrier permeability, behaviors, hippocampus local EEG, and brain oxidative stress in ischemic rats exposed to dusty particulate matter. Environ Sci Pollut Res Int. 2020; 27(5):5281-5292. [view at publisher] [DOI] [Google Scholar]
36. Sarkaki A, Farbood Y, Gharib-Naseri MK, Badavi M, Mansouri MT, Haghparast A, Mirshekar MA. Gallic acid improved behavior, brain electrophysiology, and inflammation in a rat model of traumatic brain injury. Can J Physiol Pharmacol. 2015; 93(8):687-94. [view at publisher] [DOI] [Google Scholar]
37. Farbood Y, Sarkaki A, Hashemi S, Mansouri MT, Dianat M. The effects of gallic acid on pain and memory following transient global ischemia/reperfusion in Wistar rats. Avicenna J Phytomed. 2013; 3(4):329-40. [Google Scholar]
38. Maya S, Pakash T, Goli D. Evaluation of neuroprotective effects of wedelolactone and gallic acid on aluminium-induced neurodegeneration: Relevance to sporadic amylotrophic lateral sclerosis. Euro J Phamacol. 2018; 835:41-51. [view at publisher] [DOI] [Google Scholar]
39. Zhu JX, Shan JL, Hu WQ, Zeng JX, Shu JC. Gallic acid activates hippocampal BDNF-Akt-mTOR signaling in chronic mild stress. Metab Brain Dis. 2019; 34(1):93-101. [DOI] [Google Scholar]
40. Yadav M, Jindal DK, Dhingra MS, Kumar A, Parle M, Dhingra S. Protective effect of gallic acid in experimental model of ketamine-induced psychosis: possible behaviour, biochemical, neurochemical and cellular alterations. Inflammopharmacology. 2018;26(2):413-424. [view at publisher] [DOI] [Google Scholar]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
