Volume 8, Issue 4 (12-2020)                   Jorjani Biomed J 2020, 8(4): 34-41 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Heidarpour S, Ghahramani M, Hosseinpour Delavar S. The Effect of Eight Weeks of Moderate-Intensity Endurance Training on Myocardial Capillary Density, Ejection Fraction and Left Ventricular Shortening Fraction in Male Rats with Myocardial Infarction. Jorjani Biomed J. 2020; 8 (4) :34-41
URL: http://goums.ac.ir/jorjanijournal/article-1-776-en.html
1- Department of Exercise Physiology, Borujerd Branch, Islamic Azad University, Borujerd, Iran
2- Department of Exercise Physiology, Gilan-E-Gharb Branch, Islamic Azad University, Gilan-E-Gharb, Iran , m.ghahramani@iauggh.ac.ir
3- Department of Exercise Physiology, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran
Abstract:   (385 Views)
Background and Objective: Vascular obstruction and impaired blood flow and oxygen delivery cause a myocardial infarction and limit a personchr('39')s function. Therefore, finding a way to create new arteries and replace blocked arteries has always been of interest to researchers, including exercise physiologists. Therefore, this study was conducted to evaluate the effect of eight weeks of moderate-intensity endurance training on the capillary density of the myocardium and ejection fraction and left ventricular shortening fraction in male rats with myocardial infarction.
Material and Methods: 16 ten-week-old male wistar rats with mean weight of 250-300gr were allocated to two groups of experimental (60 minutes of interval treadmill running for four minutes at an intensity of 65-70% VO2max and two minutes of active rest at 50-60 percent of VO2max for 5 days a week for 8 weeks) and control group (without any training). Immunohistochemistry was used to measure the capillary density of the myocardium. Ejection fraction and left ventricular shortening fraction were measured by Doppler echocardiography. Data were analyzed in SPSS18 using independent samples t test (α≤ 0.05).
Results: The findings showed that there was a significant increase in the capillary density of the myocardium (p=0.000), ejection fraction (P = 0.001) and left ventricular shortening fraction (P = 0.001) in the experimental group as compared with the control group.
Conclusion: In general, eight weeks of moderate-intensity endurance training can effectively increase angiogenesis in male Wistar rats after MI. 
Full-Text [PDF 389 kb]   (149 Downloads) |   |   Full-Text (HTML)  (35 Views)  
Type of Article: Brief Report | Subject: Health
Received: 2020/10/1 | Accepted: 2020/10/14 | Published: 2020/11/30

1. Shasavari S, Nazari F, Karimyar Jahromi M, Sadeghi M. Epidemiological study of hospitalized cardiovascular patients in Jahrom hospitals in 2012-2013. Cardiovascular Nursing Journal 2013; Summer؛(2).(Persian)
2. Fox S, Gasparini G, Harris A. Angiogenesis pathological, prognosis, and their link to trial design and anticancer drugs. Lancet Oncol.2001;2: 278-89. [DOI]
3. Mooren F , Völker K. Molecular and Cellular Exercise Physiology.7: Human Kinetics.2004; 451.
4. Wilmore JH. Costill DL. Kenney WL. Physiology of Sport and Exercise.2008; 4th Ed. Human Kinetics.
5. Van Craenenbroeck EM, Vrints CJ, Haine SE, Vermeulen K, Goovaerts I, Van Tendeloo VF, et al. A maximal exercise bout increases the number of circulating CD34+/KDR+ endothelial progenitor cells in healthy subjects. Relation with lipid profile. J Appl Physiol.2008; 104(4): 1006-13. [DOI]
6. Gu JW, Gadonski G, Wang J, Makey I, Adair TH. Exercise increases endostatin in circulation of healthy volunteers. BMC Physiol.2004;4: 2. [DOI]
7. Nourshahi M, Taheri chadorneshin H , Ranjbar K. The stimulus of angiogenesis during exercise and physical Activity. Quarterly of the Horizon of Medical Sciences.2013; 5: 286-296.
8. KKraljevic J, Marinovic J, Pravdic D, Zubin P, Dujic Z, Wisloff U, Ljubkovic M. Aerobic interval training attenuates remodelling and mitochondrial dysfunction in the post-infarction failing rat heart. Cardiovasc Res.20013; 1;99(1):55-64. [DOI]
9. Morten A. Hoydal MA. Wisloff U. Kemi OJ. Ellingsen O. Running speed and maximal oxygen uptake in rats and mice: practical implications for exercise training. Eur J Cardiovasc Prev Rehabil.2007;14(6):753-60. [DOI:10.1097/HJR.0b013e3281eacef1]
10. Wisloff U. Helgerud J. Kemi OJ. Ellingsen O. Intensity-controlled treadmill running in rats: VO2 max and cardiac hypertrophy. Am J Physiol Heart Circ Physiol.2010; 280(3):301-10. [DOI]
11. Kemi OJ. Haram PM. Loennechen JP. Osnes J-B. Skomedal T. Wisløff U. et al.Moderate vs. high exercise intensity: differential effects on aerobic fitness , cardiomyocyte contractility, and endothelial function. Cardiovascular research. 2005; 67(1):161-72. [DOI]
12. Frisbee JC, Samora JB, Peterson J, Bryner R.Exercise training blunts microvascular rarefaction in the metabolic syndrome. Am J Physiol Heart Circ Physiol.2006; 291: 2483-2492. [DOI]
13. Frandin K, Mellstrom D, Sundh V, and Grimby G. A life span perspective on patterns of physical activity and functional performance at the age of 76. Gerontology.1995; 41: 109-120. [DOI]
14. Zagzag D. Zhong H. Scalzitti JM. Laughner E. Simons JW. Semenza GL. Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer.2000; 88(11):2606-18. [DOI]
15. Rawlins J, Bhan A, Sharma S. Left ventricular hypertrophy in athletes. Eur J Echocardiogr.2009; 10(3):350-6. [DOI]

Add your comments about this article : Your username or Email:

Send email to the article author

© 2021 All Rights Reserved | Jorjani Biomedicine Journal

Designed & Developed by : Yektaweb