Volume 8, Issue 3 (7-2020)                   Jorjani Biomed J 2020, 8(3): 44-57 | Back to browse issues page

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Amini Najafabadi B, Keshavarz S, Asgary S, Azarbarzin M. The 8-week aerobic exercise improves blood sugar، HbA1c and lipid profile in women with type 2 diabetes: A Controlled Randomized Clinical Trial. Jorjani Biomed J. 2020; 8 (3) :44-57
URL: http://goums.ac.ir/jorjanijournal/article-1-752-en.html
1- Department of Physical Education and Sports Sciences, Najafabad Branch, Islamic Azad University, Najafabad, Iran
2- Department of Physical Education and Sports Sciences, Najafabad Branch, Islamic Azad University, Najafabad, Iran/Sport Medicine Research Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran , keshavarz1357@gmail.com
3- Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
4- Nursing and Midwifery Sciences Development research Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran
Abstract:   (48 Views)
Background and objective: The effect of aerobic exercise (AE) on cardiovascular (CVD) related risk factors are still debatable. Therefore this randomized controlled clinical trial (RCT) was performed with unique and specific AE protocol to investigate the effect of eight-week AE only on female subjects with type 2 diabetes.
Material And Method: A controlled RCT was performed on 30 women with type 2 diabetes aged 30 - 50. They were randomly divided into two groups, intervention and control by block randomization method. The intervention group received an incremental AE for eight weeks, three sessions per week, max heart rate (55-75%) and rating of perceived exertion (RPE) 12-13 for 150 minutes per week. Blood samples were taken before and after each intervention for both groups to be evaluated for fasting blood sugar (FBS), hemoglobin A1c (HbA1c), lipid profile [triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C)].
Result: Eight-week AE intervention led to a significant decrease in HbA1c, FBS levels (p = 0.025, p=0.003) in experimental group compared to control however no significant differences was observed in terms of lipid profile (total cholesterol (TC), triglyceride (TG), LDL-C and HDL-C) between control and experimental group (p> 0.05). The results of paired t-test showed that FBS, TC and HbA1c levels were significantly reduced within experimental group after intervention compared to pre-test (p = 0.038, p = 0.05, p = 0.002, respectively). There was no significant difference between TG, LDL-C, and HDL-C levels within experimental group between pre and post-test (p>0.05).
Conclusion: It can be concluded that AE has been effectively reduce FBS, HbA1c and TC in women type 2 diabetes.
Full-Text [PDF 531 kb]   (19 Downloads)    
Type of Article: Original article | Subject: Health
Received: 2020/09/18 | Revised: 2020/11/15 | Accepted: 2020/07/31

References
1. Fowler MJ. Microvascular and macrovascular complications of diabetes. Clinical diabetes. 2008;26(2):77-82. [Google Scholar]
2. Gerich JE. Type 2 diabetes mellitus is associated with multiple cardiometabolic risk factors. Clinical cornerstone. 2007;8(3):53-68.
3. Nathan DM, Bayless M, Cleary P, Genuth S, Gubitosi-Klug R, Lachin JM, et al. Diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: advances and contributions. Diabetes. 2013;62(12):3976-86. [Google Scholar]
4. AD A. 2. Classification and diagnosis of diabetes. Diabetes Care. 2015;38(Suppl 1):S8-S16.
5. Napoli C, Balestrieri A, Ignarro LJ. Therapeutic approaches in vascular repair induced by adult bone marrow cells and circulating progenitor endothelial cells. Current pharmaceutical design. 2007;13(31):3245-51. [Google Scholar]
6. Medicine ACoS. American Diabetes Association (ADA). Exercise and type 2 diabetes: American College of Sports Medicine and the American Diabetes Association: joint position statement. Exercise and type 2 diabetes. Med Sci Sports Exerc. 2010;42(12):2282-303. [Google Scholar]
7. Eves ND, Plotnikoff RC. Resistance training and type 2 diabetes: considerations for implementation at the population level. Diabetes care. 2006;29(8):1933-41. [Google Scholar]
8. Stewart K. Exercise training: can it improve cardiovascular health in patients with type 2 diabetes? British journal of sports medicine. 2004;38(3):250-2. [Google Scholar]
9. Alam S, Stolinski M, Pentecost C, Boroujerdi MA, Jones RH, Sonksen PH, et al. The effect of a six-month exercise program on very low-density lipoprotein apolipoprotein B secretion in type 2 diabetes. The Journal of Clinical Endocrinology & Metabolism. 2004;89(2):688-94. [Google Scholar]
10. Sigal RJ, Kenny GP, Wasserman DH, Castaneda-Sceppa C. Physical activity/exercise and type 2 diabetes. Diabetes care. 2004;27(10):2518-39. [Google Scholar]
11. Rossi G. Association AD. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2018;33(Suppl 1):S62-S9. [Google Scholar]
12. Chudyk A, Petrella RJ. Effects of exercise on cardiovascular risk factors in type 2 diabetes: a meta-analysis. Diabetes care. 2011;34(5):1228-37. [Google Scholar]
13. Hordern MD, Dunstan DW, Prins JB, Baker MK, Singh MAF, Coombes JS. Exercise prescription for patients with type 2 diabetes and pre-diabetes: a position statement from Exercise and Sport Science Australia. Journal of Science and Medicine in Sport. 2012;15(1):25-31. [Google Scholar]
14. Mendes R, Sousa N, Almeida A, Subtil P, Guedes-Marques F, Reis VM, et al. Exercise prescription for patients with type 2 diabetes—a synthesis of international recommendations: narrative review. British journal of sports medicine. 2016;50(22):1379-81. [Google Scholar]
15. Yavari A, Hajiyev A, Naghizadeh F. The effect of aerobic exercise on glycosylated hemoglobin values in type 2 diabetes patients. Journal of sports medicine and physical fitness. 2010;50(4):501. [Google Scholar]
16. Najafipour F, Mobasseri M, Yavari A, Nadrian H, Aliasgarzadeh A, Abbasi NM, et al. Effect of regular exercise training on changes in HbA1c, BMI and VO2max among patients with type 2 diabetes mellitus: an 8-year trial. BMJ Open Diabetes Research and Care. 2017;5(1). [Google Scholar]
17. Kadoglou NP, Perrea D, Iliadis F, Angelopoulou N, Liapis C, Alevizos M. Exercise reduces resistin and inflammatory cytokines in patients with type 2 diabetes. Diabetes care. 2007;30(3):719-21. [Google Scholar]
18. Yousefipoor P, Tadibi V, Behpoor N, Parnow A, Delbari M, Rashidi S. Effects of aerobic exercise on glucose control and cardiovascular risk factor in type 2 diabetes patients. medical journal of mashhad university of medical sciences. 2015;57(9):976-84. [Google Scholar]
19. Dixit S, Maiya A, Shastry B. Effect of moderate-intensity aerobic exercise on glycosylated haemoglobin among elderly patients with type 2 diabetes & peripheral neuropathy. The Indian journal of medical research. 2017;145(1):129. [Google Scholar]
20. Sherwani SI, Khan HA, Ekhzaimy A, Masood A, Sakharkar MK. Significance of HbA1c test in diagnosis and prognosis of diabetic patients. Biomarker insights. 2016;11:BMI. S38440. [Google Scholar]
21. Selvin E, Steffes MW, Zhu H, Matsushita K, Wagenknecht L, Pankow J, et al. Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. New England Journal of Medicine. 2010;362(9):800-11. [Google Scholar]
22. Sigal RJ, Kenny GP, Boulé NG, Wells GA, Prud'homme D, Fortier M, et al. Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Annals of internal medicine. 2007;147(6):357-69. [Google Scholar]
23. Marcus RL, Smith S, Morrell G, Addison O, Dibble LE, Wahoff-Stice D, et al. Comparison of combined aerobic and high-force eccentric resistance exercise with aerobic exercise only for people with type 2 diabetes mellitus. Physical therapy. 2008;88(11):1345-54. [Google Scholar]
24. Church TS, Blair SN, Cocreham S, Johannsen N, Johnson W, Kramer K, et al. Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial. Jama. 2010;304(20):2253-62. [Google Scholar]
25. Bello AI, Owusu-Boakye E, Adegoke BO, Adjei DN. Effects of aerobic exercise on selected physiological parameters and quality of life in patients with type 2 diabetes mellitus. International journal of general medicine. 2011;4:723. [Google Scholar]
26. Schrot RJ. Targeting plasma glucose: preprandial versus postprandial. Clinical Diabetes. 2004;22(4):169-72. [Google Scholar]
27. Misra A, Alappan NK, Vikram NK, Goel K, Gupta N, Mittal K, et al. Effect of supervised progressive resistance-exercise training protocol on insulin sensitivity, glycemia, lipids, and body composition in Asian Indians with type 2 diabetes. Diabetes care. 2008;31(7):1282-7. [Google Scholar]
28. Cauza E, Hanusch-Enserer U, Strasser B, Ludvik B, Metz-Schimmerl S, Pacini G, et al. The relative benefits of endurance and strength training on the metabolic factors and muscle function of people with type 2 diabetes mellitus. Archives of physical medicine and rehabilitation. 2005;86(8):1527-33. [Google Scholar]
29. Shenoy S, Arora E, Jaspal S. Effects of progressive resistance training and aerobic exercise on type 2 diabetics in Indian population. Int J Diabetes Metab. 2009;17(1):27-30. [Google Scholar]
30. Tokmakidis SP, Zois CE, Volaklis KA, Kotsa K, Touvra A-M. The effects of a combined strength and aerobic exercise program on glucose control and insulin action in women with type 2 diabetes. European journal of applied physiology. 2004;92(4-5):437-42. [Google Scholar]
31. Zhang Q-J, Li Q-X, Zhang H-F, Zhang K-R, Guo W-Y, Wang H-C, et al. Swim training sensitizes myocardial response to insulin: role of Akt-dependent eNOS activation. Cardiovascular research. 2007;75(2):369-80. [Google Scholar]
32. Al-Goblan AS, Al-Alfi MA, Khan MZ. Mechanism linking diabetes mellitus and obesity. Diabetes, metabolic syndrome and obesity: targets and therapy. 2014;7:587. [Google Scholar]
33. Ersoy C, Imamoglu S, Budak F, Tuncel E, Erturk E, Oral B. Effect of amlodipine on insulin resistance & tumor necrosis factor-alpha levels in hypertensive obese type 2 diabetic patients. Indian J Med Res. 2004;120(5):481-8. [Google Scholar]
34. Motahari-Tabari N, Shirvani MA, Shirzad-e-Ahoodashty M, Yousefi-Abdolmaleki E, Teimourzadeh M. The effect of 8 weeks aerobic exercise on insulin resistance in type 2 diabetes: a randomized clinical trial. Global journal of health science. 2015;7(1):115. [Google Scholar]
35. Detection NCEPEPo, Adults ToHBCi. Third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III): National Cholesterol Education Program, National Heart, Lung, and Blood …; 2002. [Google Scholar]
36. Kizilci S. Physical Activity Level and Related Factors of Diabetic Adults According to Gender. International Journal of Caring Sciences. 2017;10(3):1478-89. [Google Scholar]
37. Olson TP, Dengel D, Leon A, Schmitz K. Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women. International journal of obesity. 2007;31(6):996-1003. [Google Scholar]
38. Almeida MB, Araújo CGS. Effects of aerobic training on heart rate. Revista Brasileira de Medicina do Esporte. 2003;9(2):113-20. [Google Scholar]
39. Nayebifar S, Afzalpour ME, Kazemi T, Abtahi Eivary SH, Mogharnasi M. Changes in blood pressure, body composition, and Vo2max after 10 weeks of high intense interval training and ginger consumption in overweight women. Qom University of Medical Sciences Journal. 2017;11(6):19-27. [Google Scholar]
40. Colberg SR, Sigal RJ, Fernhall B, Regensteiner JG, Blissmer BJ, Rubin RR, et al. Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes care. 2010;33(12):e147-e67. [Google Scholar]
41. Baharloo S, Taghian F, Hedayati M. Effects of aerobic exercise on C-reactive protein and lipid profile in subclinical hypothyroidism among overweight obese women. Pathobiology Research. 2014;17(1):91-102. [Google Scholar]
42. Kraus WE, Houmard JA, Duscha BD, Knetzger KJ, Wharton MB, McCartney JS, et al. Effects of the amount and intensity of exercise on plasma lipoproteins. New England Journal of Medicine. 2002;347(19):1483-92. [Google Scholar]
43. King D, Brughelli M, Hume P, Gissane C. Assessment, management and knowledge of sport-related concussion: systematic review. Sports medicine. 2014;44(4):449-71. [Google Scholar]
44. MEMBERS WG, Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, et al. Heart disease and stroke statistics—2012 update: a report from the American Heart Association. Circulation. 2012;125(1):e2. [Google Scholar]
45. Basa AL, Garber AJ. Cardiovascular disease and diabetes: Modifying risk factors other than glucose control. Ochsner Journal. 2001;3(3):132-7. [Google Scholar]
46. Vergès B. Lipid modification in type 2 diabetes: the role of LDL and HDL. Fundamental & clinical pharmacology. 2009;23(6):681-5. [Google Scholar]
47. Esfarjani F, Rashidi F, Marandi SM. The effect of aerobic exercise on blood glucose, Lipid Profile and Apo. Journal of Ardabil University of Medical Sciences. 2013;13(2):132-41. [Google Scholar]
48. Sato Y. Overview of Exercise Prescription for Diabetes Patients and Its Application in Japan. Journal of Science in Sport and Exercise. 2020:1-10. [Google Scholar]

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