Volume 8, Issue 2 (7-2020)                   Jorjani Biomed J 2020, 8(2): 1-3 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Khosravi A. Biological characteristics of Stem Cells from Human Exfoliated Deciduous Teeth (SHEDs) and its therapeutic applications in regenerative medicine. Jorjani Biomed J. 2020; 8 (2) :1-3
URL: http://goums.ac.ir/jorjanijournal/article-1-734-en.html
Stem cell research center, Golestan University of Medical Sciences, Gorgan, Iran/ Department of Molecular Medicine, Faculty of Advanced Medical Technologies, Golestan University of Medical Sciences, Gorgan, Iran. , khosravia@goums.ac.ir
Abstract:   (1924 Views)
Stem cells isolated from human exfoliated deciduous teeth (SHEDs) are multipotent mesenchymal stem cells that are isolated from dental pulp tissues. These cells have a high proliferative capacity, multipotential ability, immunomodulatory function, and minimal risk of oncogenesis. Recent studies have shown that SHEDs are a feasible cell source for cell therapy and regenerative medicine.
Full-Text [PDF 263 kb]   (921 Downloads) |   |   Full-Text (HTML)  (339 Views)  
Type of Article: Review Article | Subject: Molecular Sciences
Received: 2020/02/22 | Accepted: 2020/05/29 | Published: 2020/07/1

1. Wang M, Yuan Q, Xie L. Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application. Stem Cells Int. 2018;2018:3057624. [view at publisher] [DOI] [Google Scholar]
2. Taguchi T, Yanagi Y, Yoshimaru K, Zhang XY, Matsuura T, Nakayama K, et al. Regenerative medicine using stem cells from human exfoliated deciduous teeth (SHED): a promising new treatment in pediatric surgery. Surg Today. 2019;49(4):316-22. [view at publisher] [DOI] [Google Scholar]
3. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8(4):315-7. [view at publisher] [DOI] [Google Scholar]
4. Shi X, Mao J, Liu Y. Pulp stem cells derived from human permanent and deciduous teeth: Biological characteristics and therapeutic applications. Stem Cells Transl Med. 2020;9(4):445-64. [view at publisher] [DOI] [Google Scholar]
5. Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, et al. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A. 2003;100(10):5807-12. [DOI] [Google Scholar]
6. Sakai VT, Zhang Z, Dong Z, Neiva KG, Machado MA, Shi S, et al. SHED differentiate into functional odontoblasts and endothelium. J Dent Res. 2010;89(8):791-6. [DOI]
7. Yamaza T, Kentaro A, Chen C, Liu Y, Shi Y, Gronthos S, et al. Immunomodulatory properties of stem cells from human exfoliated deciduous teeth. Stem Cell Res Ther. 2010;1(1):5. [view at publisher] [DOI] [Google Scholar]
8. Kanafi MM, Rajeshwari YB, Gupta S, Dadheech N, Nair PD, Gupta PK, et al. Transplantation of islet-like cell clusters derived from human dental pulp stem cells restores normoglycemia in diabetic mice. Cytotherapy. 2013;15(10):1228-36. [view at publisher] [DOI] [Google Scholar]
9. Izumoto-Akita T, Tsunekawa S, Yamamoto A, Uenishi E, Ishikawa K, Ogata H, et al. Secreted factors from dental pulp stem cells improve glucose intolerance in streptozotocin-induced diabetic mice by increasing pancreatic beta-cell function. BMJ Open Diabetes Res Care. 2015;3(1):e000128. [view at publisher] [DOI] [Google Scholar]
10. Yamagata M, Yamamoto A, Kako E, Kaneko N, Matsubara K, Sakai K, et al. Human dental pulp-derived stem cells protect against hypoxic-ischemic brain injury in neonatal mice. Stroke. 2013;44(2):551-4. [DOI] [Google Scholar]
11. Sonoda S, Tomoda E, Tanaka Y, Yamaza T. Properties and possibilities of human dental pulp-derived stem cells. Arch Stem Cell Res. 2015;2(2):1012. [Google Scholar]

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | Jorjani Biomedicine Journal

Designed & Developed by : Yektaweb