Volume 7, Issue 3 (9-2019)                   Jorjani Biomed J 2019, 7(3): 1-3 | Back to browse issues page

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Saghaeian Jazi M. SOX2OT, a long non-coding RNA involved in autophagy regulation. Jorjani Biomed J. 2019; 7 (3) :1-3
URL: http://goums.ac.ir/jorjanijournal/article-1-673-en.html
Stem Cell Research Center, Golestan University of Medical Sciences, Gorgan, Iran , marie.saghaeian@yahoo.com
Abstract:   (361 Views)
Summary:
SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA associated with cancer pathogenesis. It contributes to a variety of cellular functions and recent evidence propounds its association with autophagy process. It has been showed that SOX2OT can regulate the expression of different autophagy associated factors in human cells with different mechanisms, however more remains to be investigated.
Full-Text [PDF 223 kb]   (140 Downloads)    
Type of Article: Letter to Editor | Subject: Molecular Sciences
Received: 2020/01/19 | Revised: 2020/04/30 | Accepted: 2020/01/20

References
1. Shahryari A, Jazi MS, Samaei NM, Mowla SJ. Long non-coding RNA SOX2OT: expression signature, splicing patterns, and emerging roles in pluripotency and tumorigenesis. Frontiers in genetics. 2015;6:196. [view at publisher] [DOI] [Google Scholar]
2. Fantes J, Ragge NK, Lynch S-A, McGill NI, Collin JRO, Howard-Peebles PN, et al. Mutations in SOX2 cause anophthalmia. Nature genetics. 2003;33(4):462. [view at publisher] [DOI] [Google Scholar]
3. Amaral PP, Neyt C, Wilkins SJ, Askarian-Amiri ME, Sunkin SM, Perkins AC, et al. Complex architecture and regulated expression of the Sox2ot locus during vertebrate development. Rna. 2009;15(11):2013-27. [view at publisher] [DOI] [Google Scholar]
4. Wang Y, Wu N, Luo X, Zhang X, Liao Q, Wang J. SOX2OT, a novel tumor-related long non-coding RNA. Biomedicine & Pharmacotherapy. 2020;123:109725. [view at publisher] [DOI] [Google Scholar]
5. Wang W, Chen D, Zhu K. SOX2OT variant 7 contributes to the synergistic interaction between EGCG and Doxorubicin to kill osteosarcoma via autophagy and stemness inhibition. Journal of Experimental & Clinical Cancer Research. 2018;37(1):37. [view at publisher] [DOI] [Google Scholar]
6. Yin D, Zheng X, Zhuang J, Wang L, Liu B, Chang Y. Downregulation of long noncoding RNA Sox2ot protects PC‐12 cells from hydrogen peroxide-induced injury in spinal cord injury via regulating the miR‐211‐myeloid cell leukemia‐1 isoform2 axis. Journal of cellular biochemistry. 2018;119(12):9675-84. [view at publisher] [DOI] [Google Scholar]
7. Zhang Y, Chang B, Zhang J, Wu X. LncRNA SOX2OT alleviates the high glucose-induced podocytes injury through autophagy induction by the miR-9/SIRT1 axis. Experimental and molecular pathology. 2019;110:104283. [view at publisher] [DOI] [Google Scholar]
8. Khandia R, Dadar M, Munjal A, Dhama K, Karthik K, Tiwari R, et al. A comprehensive review of autophagy and its various roles in infectious, non-infectious, and lifestyle diseases: current knowledge and prospects for disease prevention, novel drug design, and therapy. Cells. 2019;8(7):674. [view at publisher] [DOI] [Google Scholar]

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