Volume 6, Issue 3 (9-2018)
Jorjani Biomed J 2018, 6(3): 1-13 |
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Nazari-Vanani R, Sattarahmady N, Azarpira N, Heli H. Introducing Self-Nanoemulsifying Drug Delivery System to Increase the Bioavailability of Oral Medications. Jorjani Biomed J 2018; 6 (3) :1-13
URL: http://goums.ac.ir/jorjanijournal/article-1-619-en.html
URL: http://goums.ac.ir/jorjanijournal/article-1-619-en.html
1- Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2- Department of Physical Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3- Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4- Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran , hheli7@yahoo.com
2- Department of Physical Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3- Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4- Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran , hheli7@yahoo.com
Abstract: (4883 Views)
Due to low cost, ease of administration, and lack need for trained personnel, the oral route is the most convenient and accessible way to design different medicines that could be simply consumed by patients. Regardless of the great benefits of this route, the main challenge in the bioavailability of oral medications is gastrointestinal instability. Nanotechnology is used to improve the solubility and bioavailability of poorly water-soluble drugs. The self-nanoemulsifying drug delivery system is an ideal method for improving the solubility and bioavailability of poorly water-soluble drugs. This system is a sustainable combination of drugs, oils, surfactants, and cosurfactants. The combination of these components causes the nanoemulsion of oil in water with the size of droplets in the range of nm, thereby increasing the bioavailability and oral absorption of poorly water-soluble drugs. This system is highly regarded for its benefits and the ability to improve the healing properties of oral medications.
Type of Article: Review Article |
Subject:
Basic Medical Sciences
Received: 2018/04/22 | Accepted: 2018/09/18 | Published: 2019/01/2
Received: 2018/04/22 | Accepted: 2018/09/18 | Published: 2019/01/2
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