Volume 6, Issue 3 (Autumn 2018)                   Jorjani Biomed J 2018, 6(3): 63-71 | Back to browse issues page

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Roustaeizade Z, Akhavan Karbassi M H, Kheirollahi K, Babaei zarch E. Therapeutic Efficacy of Different Concentrations of Myrtus communis (Essential oil of common myrtle) in the Treatment of Recurrent Aphthous Stomatitis: A Randomized Controlled Clinical Trial. Jorjani Biomed J. 2018; 6 (3) :63-71
URL: http://goums.ac.ir/jorjanijournal/article-1-618-en.html
1- Department of Oral Medicine, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- Faculty of Dentistry, Shahid Sadoughi University of Medical Science, Yazd, Iran , drbabaei.dds@gmail.com
Abstract:   (1242 Views)
Background and objectives: Recurrent aphthous stomatitis (RAS) is a painful ulcerative lesion and its incidence is 20% in the society. Myrtus communis (myrtex) has been effective in the treatment of RAS. In this study, two different concentrations (2.5% versus 5%) of myrtex extract were evaluated to discover the most effective concentration for the treatment of RAS.
Methods: In this randomized, double-blind clinical trial, 60 patients with RAS were evaluated. Thirty patients used myrtex extract 5% and thirty patients used myrtex extract 2.5% (10 drops on lesion for 20 seconds 5 times per day). The severity of pain and burning sensation experienced by patients were measured by visual analogue scale (VAS) and the size of the lesion was estimated by transparent calibrated grid Data analysis was done by running t-test and repeated measures statistical test.
Results: The mean of the largest RAS diameter before treatment was decreased in both groups 1 day and 7 days after treatment (P-value=0.000); however, these differences were not significant in both groups (P-value =0.401). Furthermore, the severities of pain and burning sensation were decreased in both groups (p-value = 0.000). Nevertheless, this decrease was similar in both groups (P-value = 964).
Conclusion: Treatment with different concentrations of myrtex extract is effective in decreasing RAS diameter, pain, and burning sensation. In addition, the therapeutic efficacy of two different concentrations of myrtex extract (2.5% and 5%) was similar in this regard.
Full-Text [PDF 1084 kb]   (472 Downloads)    
Type of Article: Original article | Subject: General medicine
Received: 2018/08/30 | Revised: 2020/01/27 | Accepted: 2018/09/20

1. Greenberg M, Glick M, Ship J. Burket'soral Medicine. Eleven Editions. In. Hamilton: BC Decker; 2008. p. 57-60.
2. Jurge S, Kuffer R, Scully C, Porter SR. Mucosal disease series. Number VI. Recurrent aphthous stomatitis. Oral Dis 2006;12(1):1-21. [DOI:10.1111/j.1601-0825.2005.01143.x]
3. Koybasi S, Parlak AH, Serin E, Yilmaz F, Serin D. Recurrent aphthous stomatitis: investigation of possible etiologic factors. Am J Otolaryngol 2006;27(4):229-32. [DOI:10.1016/j.amjoto.2005.09.022]
4. Archana JPA, Prabhakaran ACJ. Pharmacotherapy of recurrent aphthous ulcers. Chron Young Sci 2011;2(3):134-8. [DOI:10.4103/2229-5186.90889]
5. Scully C, Porter S. Oral mucosal disease: recurrent aphthous stomatitis. Br J Oral Maxillofac Surg 2008;46(3):198-206. [DOI:10.1016/j.bjoms.2007.07.201]
6. McBride DR. Management of aphthous ulcers. Am Fam Physician 2000;62(1):149-54, 160.
7. Altenburg A, Abdel-Naser MB, Seeber H, Abdallah M, Zouboulis CC. Practical aspects of management of recurrent aphthous stomatitis. J Eur Acad Dermatol Venereol 2007;21(8):1019- 26. [DOI:10.1111/j.1468-3083.2007.02393.x]
8. Amanlou M, Babaee N, Saheb-Jamee M, Salehnia A, Farsam H, Tohidast-Akrad Z. Efficacy of Satureja khuzistanica extract and its essential oil preparations in the management of recurrent aphthous stomatitis. Daru J Pharm Sci 2007;15(4):231-5.
9. Caglayan F, Miloglu O, Altun O, Erel O, Yilmaz AB. Oxidative stress and myeloperoxidase levels in saliva of patients with recurrent aphthous stomatitis. Oral Dis 2008;14(8):700-4. [DOI:10.1111/j.1601-0825.2008.01466.x]
10. Bakhtiari S, Azimi-Hosseini S, Ghaemmaghami A. Review of routine therapeutic management of common oral lesions. J Dent Sch 2008;25(4):348-56.
11. Zargari A. Medicinal Plants. Tehran: Tehran University; 1995.
12. Ghasemi-Dehkordi NA, Sajadi SE, Ghanadi AR, Amanzadeh Y, Azadbakht M, Asghari GR, et al. Iranian herbal pharmacopoeia (IHP). Hakim Res J 2003;6(3):63-9.
13. Oulia P, Saderi H, Aghaei H, Yaraee R, Zaeri F. The effect of Myrtus communis L. essential oil on treatment of Herpes simplex infection in animal model. Iranian J Med Aromat Plants 2007;23(2):157-65.
14. Romani A, Coinu R, Carta S, Pinelli P, Galardi C, Vincieri FF, et al. Evaluation of antioxidant effect of different extracts of Myrtus communis L. Free Radic Res 2004;38(1):97-103. [DOI:10.1080/10715760310001625609]
15. Feißt C, Franke L, Appendino G, Werz O. Identification of molecular targets of the oligomeric nonprenylated acylphloroglucinols from Myrtus communis and their implication as anti-inflammatory compounds. J Pharmacol Exp Ther 2005;315(1):389-96. [DOI:10.1124/jpet.105.090720]
16. Mendes MM, Gazarini LC, Rodrigues ML. Acclimation of Myrtus communis to contrasting Mediterranean light environments - effects on structure and chemical composition of foliage and plant water relations. Environ Exp Bot 2001;45(2):165-178. [DOI:10.1016/S0098-8472(01)00073-9]
17. Azadbakht M, Ziaiye H, Abdollahi F, Shabankhani B. Effect of Methanolic essence and extract of Myrtus Communis on Trichomonas Vaginalis. J Med Faculty Guilan Univ Med Sci 2004;12(48):8-13.
18. Khalighi-Sigaroodi F, Jarvandi S, Taghizadeh M. Therapeutic Indications of Medicinal Plants. Tehran: Arjmand; 2010.
19. Azimi S, Badiei B. The effect of Myrtle on aphthous ulcers in oral cavity. J Qazvin Univ Med Sci 1998;2(2):3-9.
20. Houshmand B, Mortazavi H, Alikhani Y, Abdolsamadi H, AhmadiMotemayel F, ZareMahmoudabad R. In vitro evaluation of antibacterial effect of myrtus extract with different concentrations on some oral bacteria. J Mashhad Dent Sch 2011;35(2):123-30.
21. Corrocher G, Di Lorenzo G, Martinelli N, Mansueto P, Biasi D, Nocini PF, et al. Comparative effect of tacrolimus 0.1% ointment and clobetasol 0.05% ointment in patients with oral lichen planus. J Clin Periodontol 2008;35(3):244-9. [DOI:10.1111/j.1600-051X.2007.01191.x]
22. Gorouhi F, Solhpour A, Beitollahi JM, Afshar S, Davari P, Hashemi P, et al. Randomized trial of pimecrolimus cream versus triamcinolone acetonide paste in the treatment of oral lichen planus. J Am Acad Dermatol 2007;57(5):806-13. [DOI:10.1016/j.jaad.2007.06.022]
23. Gallagher EJ, Bijur PE, Latimer C, Silver W. Reliability and validity of a visual analog scale for acute abdominal pain in the ED. Am J Emerg Med 2002;20(4):287-90. [DOI:10.1053/ajem.2002.33778]
24. Suresh K. An overview of randomization techniques: An unbiased assessment of outcome in clinical research. J Hum Reprod Sci 2011;4(1):8-11. [DOI:10.4103/0974-1208.82352]
25. Rad F, Yaghmaee R, MehdiAbadi P, Khatibi R. A comparative clinical trial of topical triamcinolone (adcortyle) and a herbal solution for the treatment of minor aphthous stomatitis. Armaghane Danesh Bimonthly J 2010;15(3):191- 8.
26. Taheri JB, Amin-Tavakoli M, Shahrokhi M. Comparison of the effects of myrtle and adcortyl on the treatment of minor oral aphthovs lesions. J Dent Sch 2003;20(4):608-16.
27. Khazaeli P, Chamani G, Mehrabani M, Mohammadi N. Formulation and clinical evaluation of Myrtus Mucoadhesive paste in the treatment of recurrent aphthous stomatitis. J Dent Sch 2005;23(3):429-37.

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