Volume 6, Issue 1 (Spring 2018 2018)                   Jorjani Biomed J 2018, 6(1): 12-21 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Yahyaei B, Nouri M, Matmir H. Healing effects of Ziziphus jujuba hydroalcoholic extract with exercise training on histopathological changes of male wistar rats testicular tissue in response to Boldenone steroid administration. Jorjani Biomed J. 2018; 6 (1) :12-21
URL: http://goums.ac.ir/jorjanijournal/article-1-588-en.html
1- Department of Basic Science, Faculty of Medical Sciences, Shahrood Branch, Islamic Azad University, Shahrood, Iran , behroozyahyaei@yahoo.com
2- Department of Obstetrics and Gynecology, Faculty of Medical Sciences, Shahrood Branch, Islamic Azad University, Shahrood, Iran
Abstract:   (929 Views)
Background and objectives: Anabolic steroids are routinely consumed by athletes. Therefore, this study was conducted to investigate the effect of Boldenone (BOL) on testicular tissue and the healing effect of jujube (Ziziphus jujuba) hydroalcoholic extract in addition to physical exercise.
Methods: In the present case–control study, 42 male wistar rats were purchased and divided into 3 experimental groups. 28 rats were subjected to BOL injection and subsequently divided into 4 groups. The control group, Sham and 8-week BOL group which was also divided into 4 subsequent groups of controlling BOL complications after 8 weeks, untreated control, jujube extract and jujube extract along with physical exercise.
Results: In the present study we found that jujube extract exerted healing effects on all groups pf treated rats in addition to the exercise training groups.
Conclusion: Jujube extract along with physical exercise may exert healing effects on testicular tissue after administration of anabolic BOL steroid.
Full-Text [PDF 589 kb]   (321 Downloads)    
Type of Article: Original article | Subject: Basic Medical Sciences
Received: 2018/08/19 | Revised: 2018/10/20 | Accepted: 2018/08/19

References
1. Ahmed F. AlDomairy MD. Histological and Ultrastructural Study of the Effect of Nandrolone on the Testis of Adult Male Albino Rat. Journal of American Science. 2013; 35(11):102-9.
2. Foss GL. Some experiences with a new anabolic steroid (methandrostenolone). Br Med J 2012; 1(5182):1300-1305. [DOI:10.1136/bmj.1.5182.1300]
3. Llewelynn W.Dianabol (methandrostenolone, methandienone). In: Llewelynn W (ed) Anabolics, 9th edn. Jupiter, Florida, 2009; 9: 207-211.
4. Huie MJ. An acute myocardial infarction occurring in an anabolic steroid user. Med. Sci. Sports Exerc 2004; 26:408-13. [DOI:10.1249/00005768-199404000-00002]
5. Karbalay-Doust S, Noorafshan A, Ardekani FM, Mirkhani H. The reversibility of sperm quality after discontinuing nandrolone decanoate in adult male rats. Asian J. Androl 2010; 9(2):235-9. [DOI:10.1111/j.1745-7262.2007.00203.x]
6. Lewis MI, Horvitz GD, Clemmons DR, Fournier M. Role of IGF-I and IGFbinding proteins within diaphragm muscle in modulating the effects of nandrolone. Am. J. Physiol. Endocrinol. Metab 2012; 282(2):483-90. [DOI:10.1152/ajpendo.00191.2001]
7. Louis E, Raue U, Yang Y, Jemiolo B, Trappe S. Time course of proteolytic, cytokine, and myostatin gene expression after acute exercise in human skeletal muscle. J Appl Physiol 2009; 103(5):1744-1751. [DOI:10.1152/japplphysiol.00679.2007]
8. Doaaz N, ChicoJuan J, Cabrera B, Octavio P. Luzardo. Evaluation of acute and chroni hepatotoxic effects exertedby anabolic - androgenic steroid stanozolol in adult male rats Organ Toxic Ity and Mechansims 2011; 23(10): 472 -465.
9. Noorafshan A, Karbalay-Doust S, Ardekani FM. High doses of nandrolone decanoate reduce volume of testis and length of seminiferous tubules in rats. Acta Pathologica Microbiologica et Immunologica Scandinavica 2012; 113(2):122-5. [DOI:10.1111/j.1600-0463.2005.apm1130205.x]
10. Parr MK, Flenker U, Schänzer W. Sports-related issues and biochemistry of natural and synthetic anabolic substances. Endocrinol Metab Clin North Am 2012; 39(1):45-57. [DOI:10.1016/j.ecl.2009.11.004]
11. Forbes D, Jackman M, Bishop A, Thomas M, Kambadur R, Sharma M. Myostatin auto-regulates its expression by feedback loop through Smad7 dependent mechanism. J Cell Physiol 2013; 206:264-272. [DOI:10.1002/jcp.20477]
12. Aoki MS, Soares AG, Miyabara EH, Baptista IL, Moriscot AS. Expression of genes related to myostatin signaling during rat skeletal muscle longitudinal growth. Muscle Nerve 2010; 40(6):992-999. [DOI:10.1002/mus.21426]
13. Boada LD, Zumbado M, Torres S, Lopez A, Diaz-Chico BN, Cabrera JJ, et al. Evaluation of acute and chronic hepatotoxic effects exerted by anabolic-androgenic steroid stanozolol in adult male rats. Arch Toxicol 2009; 73:465-472. [DOI:10.1007/s002040050636]
14. Bogdanovich S, Krag TO, Barton ER, Morris LD, Whittemore LA, Ahima RS, et al. Functional improvement of dystrophic muscle by myostatin blockade. Nature 2010; 420:418-421. [DOI:10.1038/nature01154]
15. Bogdanovich S, Perkins KJ, Krag TO, Whittemore LA, Khurana TS. Myostatin propeptide-mediated amelioration of dystrophic pathophysiology. FASEB J 2010; 19(6):543-549. [DOI:10.1096/fj.04-2796com]
16. Sadeghi M.1 MSc, Abbassi Daloii A.* PhD, Ziaolhagh S.J.2 PhDEffect of 6 Weeks of Resistance Training and Boldenone Supplementation on 5-alpha Reductase and Aromatase Gene Expression in Testes Tissue of Male Wistar Rats2017
17. Hartgens F, Kuipers H. Effects of androgenic-anabolic steroids in athletes. Sports Med. 2004;34(8):513-54. [DOI:10.2165/00007256-200434080-00003]
18. Jin Y, Penning TM. Steroid 5α-reductase and 3α- hydroxysteroid dehydrogenases: Key enzymes in androgen metabolism. Best Pract Res Clin Endocrinol Metab. 2001;15:79-94 [DOI:10.1053/beem.2001.0120]
19. Ou XM, Storring JM, Kushwaha N, Albert PR Heterodimerization of mineralocorticoid and glucocor- ticoid receptors at a novel negative response element of the 5-HT1 A receptor gene. J Biol Chem. 2001;276 (17):14299-307. [DOI:10.1074/jbc.M005363200]
20. Bhasin S, Storer TW, Berman N, Berman N, Callegari C, Clevenger B, et al. The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. New Engl J Med. 1996;335:1-7. [DOI:10.1056/NEJM199607043350101]
21. Shen X, TangY, et al. 2009. The protective effect of zizyphus jujube fruit on carbon tetrachloride- induce hepatic injury in mice by anti-oxidative activities. Journal of Ethnoph armacology 122: 555-60. [DOI:10.1016/j.jep.2009.01.027]
22. Dongying W, Yan J, et al. 2012. Antioxidative and hepatoprotective effects of the polysaccharides from Zizyphus jujube cv. Shaanbeitanzao. Carbohydrate Polymers 88: 1453- 1459. [DOI:10.1016/j.carbpol.2012.02.046]

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


© 2019 All Rights Reserved | Jorjani Biomedicine Journal

Designed & Developed by : Yektaweb