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:: Volume 3, Issue 2 (Autumn-winter 2015-2016 2015) ::
Jorjani Biomed J 2015, 3(2): 1-13 Back to browse issues page
Review of Phthalates Exposure and Toxicity
Samaneh Taghilou , Mirjamal Hosseini
Assistant Professor of Toxicology, Department of Toxicology and Pharmacology, School of Pharmacy, Zanjan University of Medical sciences, Zanjan, Iran , jamal_hossini@yahoo.com
Abstract:   (2634 Views)

The dialkyl- or alkyl/aryl esters of 1, 2-benzenedicarboxylic acid, which are known as Phthalates, are high-production volume synthetic chemicals and considered as environmental pollutants, due to high production and uses in community, plastics industry and common consuming products. Di-(2-ethylhexyl) phthalate (DEHP) is the most abundant phthalate in the environment. Human exposure with DEHP could be done via different chemical compounds including food packaging, household furnishings, nutritional supplements, cleaning materials and insecticides. Besides, exposure of human with phthalates occurs through different pathways such as direct contact and using Phthalate-containing products, and indirectly through leaching into other products, or general environmental contaminations. Historically, the diet has been considered the major source of phthalate exposure in the general population, but in all sources, pathways, and their relative contributions to human exposures are not well understood. Medical devices are other source of significant exposure in human. Furthermore, cosmetics, personal care products, pharmaceuticals, nutritional supplements, herbal remedies and insecticides, may result in significant but poorly quantified human exposure with this compounds. In the present review article, we tried to discuss about metabolism of phthalates in human, toxicity, monitoring of phthalates in foods, environment, and cosmetic products and then metabolites of phthalates. Finally, evaluation of human exposure through biological control is discussed.

Keywords: Phthalates, Toxicity, Environment, Medical Devices, Cosmetics, Food, Toy
Full-Text [PDF 651 kb]   (740 Downloads)    
Type of Study: Original paper | Subject: General
Received: 2016/03/19 | Accepted: 2016/03/19 | Published: 2016/03/19
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Taghilou S, Hosseini M. Review of Phthalates Exposure and Toxicity. Jorjani Biomed J. 2015; 3 (2) :1-13
URL: http://goums.ac.ir/jorjanijournal/article-1-402-en.html

Volume 3, Issue 2 (Autumn-winter 2015-2016 2015) Back to browse issues page
مجله زیست پزشکی جرجانی Jorjani Biomedicine Journal
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