Volume 12, Issue 1 (10-2024)
Jorjani Biomed J 2024, 12(1): 5-9 |
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Khandashpour M, Rakhshaie M, Sharififar R, Livani S, Abdollahi N, Soleimannejad M, et al . Long-term pulmonary assessment in Iranian severe COVID-19 ICU survivors in 2020-2021: A Cohort Study. Jorjani Biomed J 2024; 12 (1) :5-9
URL: http://goums.ac.ir/jorjanijournal/article-1-1008-en.html
URL: http://goums.ac.ir/jorjanijournal/article-1-1008-en.html
Long-term pulmonary assessment in Iranian severe COVID-19 ICU survivors in 2020-2021: A Cohort Study
Mahmoud Khandashpour1 
, Mahtab Rakhshaie2 , Rahmatollah Sharififar3 , Somayeh Livani4 , Nafiseh Abdollahi5 , Mahdi Soleimannejad6 , Fahimeh Abdollahi7 , Mahila Monajati 8
, Mahtab Rakhshaie2 , Rahmatollah Sharififar3 , Somayeh Livani4 , Nafiseh Abdollahi5 , Mahdi Soleimannejad6 , Fahimeh Abdollahi7 , Mahila Monajati 8
1- Department of Internal Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran ; Clinical Research Development Unit (CRDU), Sayad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran
2- Clinical Research Development Unit (CRDU), Sayad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran
3- Department of Infectious Diseases, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
4- Clinical Research Development Unit (CRDU), Sayad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran; Department of Radiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
5- Department of Internal Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran; Golestan Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran
6- Department of Radiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
7- Department of Internal Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
8- Golestan Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran ,mahilamonajati@gmail.com
2- Clinical Research Development Unit (CRDU), Sayad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran
3- Department of Infectious Diseases, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
4- Clinical Research Development Unit (CRDU), Sayad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran; Department of Radiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
5- Department of Internal Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran; Golestan Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran
6- Department of Radiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
7- Department of Internal Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
8- Golestan Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran ,
Abstract: (703 Views)
Background: Severe coronavirus infections may lead to long-term effects, such as persistent lung dysfunction and residual involvement. This study aimed to evaluate pulmonary function tests (PFT) and chest computed tomography (CT) scans of severe COVID-19 intensive care unit (ICU) survivors one year after discharge.
Methods: A cohort study was conducted, assessing spirometry and chest CT scans in patients with severe COVID-19 admitted to the ICU. Patients with pre-existing lung disease were excluded. Initial laboratory tests, clinical information, and medication (antivirals and corticosteroids) were reported in patients with and without fibrosis on chest CTs.
Results: Thirty patients (57% female) with a mean (SD) age of 50 (13.5) years were included. Initial pulmonary involvement had a mean score of 16 (±4), with ground-glass opacification (GGO) observed in all patients, consolidation in 88%, and pneumomediastinum in 10% of patients. One-year chest CT scans revealed mild fibrotic changes in 70% of patients, presenting as a fibrotic band (47%) or a fibrotic band with GGO (23%). Patients with fibrosis had lower serum albumin levels, lower platelet counts, and were older. One-year follow-up spirometry showed that 73% had normal results, 20% had mild obstruction, and 7% exhibited a hyperreactive airway pattern. Spirometry parameters did not significantly differ between the fibrosis and non-fibrosis groups.
Conclusion: Most patients who survived severe COVID-19 infection showed significant improvement in one-year follow-up chest CT scans, and their PFT was not severely impaired. Importantly, our findings indicate no association between the severity of initial lung involvement, medication use, and follow-up chest CT results.
Methods: A cohort study was conducted, assessing spirometry and chest CT scans in patients with severe COVID-19 admitted to the ICU. Patients with pre-existing lung disease were excluded. Initial laboratory tests, clinical information, and medication (antivirals and corticosteroids) were reported in patients with and without fibrosis on chest CTs.
Results: Thirty patients (57% female) with a mean (SD) age of 50 (13.5) years were included. Initial pulmonary involvement had a mean score of 16 (±4), with ground-glass opacification (GGO) observed in all patients, consolidation in 88%, and pneumomediastinum in 10% of patients. One-year chest CT scans revealed mild fibrotic changes in 70% of patients, presenting as a fibrotic band (47%) or a fibrotic band with GGO (23%). Patients with fibrosis had lower serum albumin levels, lower platelet counts, and were older. One-year follow-up spirometry showed that 73% had normal results, 20% had mild obstruction, and 7% exhibited a hyperreactive airway pattern. Spirometry parameters did not significantly differ between the fibrosis and non-fibrosis groups.
Conclusion: Most patients who survived severe COVID-19 infection showed significant improvement in one-year follow-up chest CT scans, and their PFT was not severely impaired. Importantly, our findings indicate no association between the severity of initial lung involvement, medication use, and follow-up chest CT results.
Type of Article: Original article |
Subject:
General medicine
Received: 2023/12/28 | Accepted: 2024/01/10 | Published: 2024/01/31
Received: 2023/12/28 | Accepted: 2024/01/10 | Published: 2024/01/31
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