en بهداشت Health تحقیقی Original article <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;"><b>Background:</b> Goalball is a distinctive athletic activity tailored for individuals who are blind or partially sighted. It is aimed at promoting physical activity and preventing sedentary behavior. This study explores the impact of high-intensity interval training (HIIT) and moderate-intensity interval training (MIIT) on muscle damage and inflammation markers in goalball players over eight weeks.<br> <b>Methods:</b> In this semi-experimental study, 24 male goalball players were randomly assigned to one of three groups: a control group, a HIIT group, and a moderate-intensity interval training (MIIT) group. The HIIT regimen involved intermittent running for 30 seconds at 100-200% of HRR, followed by 30 seconds of active recovery at 50% HRR. The MIIT protocol consisted of 25 minutes of training at 40-50% HRR, progressing to 30-35 minutes at 60-65% HRR over the last four weeks. Data were analyzed using repeated measures ANOVA, with a significance threshold set at <i>P-Value <</i>0.05.<br> <b>Results:</b> The results displayed that HIIT and MIIT had a significant effect on the concentration of CK <i>(P-Value <</i> 0.001), LDH (<i>P-Value <</i> 0.001), and IL-6 (<i>P-Value <</i> 0.001). Also, compared to MIIT, HIIT caused a significant decrease in the concentration of CK (<i>P-Value <</i> 0.001), LDH (<i>P-Value <</i> 0.001), and IL-6 (<i>P-Value <</i> 0.001).<br> <b>Conclusion</b>: HIIT exerts a more pronounced effect on CK, LDH, and IL-6 concentrations than MIIT. These findings suggest that HIIT may be more effective in enhancing physiological markers in individuals with disabilities, promoting better health outcomes.</span></span><br> &nbsp;</div> Interleukin-6, Creatine kinase, L-Lactate Dehydrogenase 15 19 http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-882-4&slc_lang=en&sid=1 Ahmed Abdulelah Abbas Al-Hadeethi ahmedtayko.aa@gmail.com 100319475328460010717 0009-0008-7636-5221 No Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan Farzaneh Taghian ft.taghian@gmail.com 100319475328460010718 100319475328460010718 Yes Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan Zaydoon Jawad Mohammed Al-Jawad dr.zaydoon@yahoo.com 100319475328460010719 100319475328460010719 No Faculty of Physical Education and Sports Sciences, University of Baghdad, Baghdad, Iraq Khosro Jalali Dehkordi khosrojalal@gmail.com 100319475328460010720 100319475328460010720 No Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan