Jorjani Biomedicine Journal
فصلنامه علمی پژوهشی زیست پزشکی جرجانی
Jorjani Biomed J
Medical Sciences
http://goums.ac.ir/jorjanijournal
1
admin
2645-3509
10.52547/jorjanibiomedj
en
jalali
1401
2
1
gregorian
2022
5
1
10
2
online
1
fulltext
en
Ameliorative Impact of Silymarin on the Male Reproductive System: An Updated Systematic Review
بهداشت
Health
مروری
Review Article
<div style="text-align: justify;"><span style="font-family:Tahoma;"><span style="font-size:12px;"><span style="line-height:200%"><span sans-serif=""><b><i><span style="line-height:200%"><span new="" roman="" times="">Background and objectives:</span></span></i></b><span style="line-height:200%"><span new="" roman="" times=""> Numerous studies have evaluated the effects of silymarin on sperm quality and its neutralization impact of various toxins on the male reproductive system. However, these studies as a whole have not been summarized and categorized yet. Silymarin is a flavonoid and known as a powerful antioxidant compound in the treatment of many diseases including liver disorders, rhinitis, diabetes, and testis disorders. The aim of the study was to discuss the impact of silymarin on the male reproductive system. </span></span></span></span><br>
<span style="line-height:200%"><span sans-serif=""><b><i><span style="line-height:200%"><span new="" roman="" times="">Material and Methods:</span></span></i></b><span style="line-height:200%"><span new="" roman="" times=""> From Apr 1998 to Feb 2020, related articles were extracted from databases of Web of Science (WOS), PubMed, Google Scholar, Science Direct, Scopus, EBSCO and grey literature by seeking MeSH words including Silymarin, Milk thistle, Silybum marianum, testis, Spermatogenesis, and Sex hormones. <b><i></i></b></span></span></span></span><br>
<span style="line-height:200%"><span sans-serif=""><b><i><span style="line-height:200%"><span new="" roman="" times="">Results: </span></span></i></b><span style="line-height:200%"><span new="" roman="" times="">Silymarin withholds damage to the testicular germinal epithelium and comforts the spermatogenesis process by amplification the antioxidant system, decrease lipid peroxidation and oxidative stress, preventing the expression of pro-apoptotic genes, increases testosterone and gonadotropins.</span></span></span></span><br>
<span style="line-height:115%"><b><i><span style="line-height:115%">Conclusion:</span></i></b><span style="line-height:115%"> In outcome, based on the results, silymarin can boost fertility in sterility males by its talented antioxidant features.</span></span></span></span><br>
</div>
Silymarin,Spermatogenesis,Gonadal Steroid Hormones,Testis,
10
23
http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-794-5&slc_lang=en&sid=1
Fahimeh
Hosseinabadi
fahimehhosseinabadi@yahoo.com
10031947532846008048
0000000335119928
No
Academic Center for Education, Culture and Research, Arak, Iran
Tayebeh
Faraji
faraji.tb@hotmail.com
10031947532846008049
0000000248772179
No
Academic Center for Education, Culture and Research, Arak, Iran
Mahdi
Malmir
m.malmir66@hotmail.com
10031947532846008050
000000017915849X
Yes
Department of Midwifery, Tuyserkan Branch, Islamic Azad University, Tuyserkan, Iran
Hanieh
Mohamadi
m.malmir1988@gmail.com
10031947532846008051
10031947532846008051
No
Department of Midwifery, Tuyserkan Branch, Islamic Azad University, Tuyserkan, Iran