Jorjani Biomedicine Journal
فصلنامه علمی پژوهشی زیست پزشکی جرجانی
Jorjani Biomed J
Medical Sciences
http://goums.ac.ir/jorjanijournal
1
admin
2645-3509
10.52547/jorjanibiomedj
en
jalali
1400
2
1
gregorian
2021
5
1
9
2
online
1
fulltext
en
Evaluation of CITED4 Gene Expression in The Cardiac Muscle of Male Rats as a Result of Resistance Exercise and Spirulina Supplement
بهداشت
Health
تحقیقی
Original article
<div style="text-align: justify;"><strong><em>Background and Objective</em></strong><strong>:</strong> Effects of resistance training and herbal supplements on cardiac signaling pathways are sparsely reported in the literature. This study aimed to evaluate the CITED4 gene expression in the cardiac muscle of male rats as a result of resistance exercise and spirulina supplementation.<br>
<strong><em>Material and Methods:</em></strong> Thirty-two rats (male - Sprague Dally) were grouped into 4 groups (1. resistance training: RE, 2. spirulina + resistance training: SP +RE, 3. spirulina platensis: SP, 4. control: Co, n = 8). The training program was performed for healthy training groups 5 sessions per week for 8 weeks. Supplementation included 200 mg/kg/ day of Spirulina for the supplement groups. Real-time PCR was used to measure gene expression. We used of Two-way ANOVA in SPSS (p<0.05).<br>
<strong><em>Results:</em></strong> In comparison with the control group, we observed a significant increase in CITED4 gene expression in RE (P= 0.001) and RE+SP (P= 0.001) groups. Also, there was a significant difference in CEBP gene expression between CO with RE (P= 0.001), SP (P= 0.034), RE+SP (P= 0.001) groups.<br>
<strong><em>Conclusion:</em></strong> Spirulina supplementation alone has no effect on the signaling pathway of cardiac hypertrophy. However, if used concomitantly with resistance training, it can affect the signal pathway of cardiac hypertrophy.</div>
CITED4,Hypertrophy,Resistance Training,Spirulina,
36
44
http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-699-5&slc_lang=en&sid=1
Abdossaleh
Zar
sa_zaras@yahoo.com
10031947532846007063
10031947532846007063
No
Department of Sport Science, School of Literature and Humanities, Persian Gulf University, Boushehr, Iran/Persian Gulf Sports, Nutrition and Health Research Team, School of Literature and Humanities, Persian Gulf University, Boushehr, Iran
Fatemeh
Ahmadi
F.ahmadi@mehr.pgu.ac.ir
10031947532846007064
0000000301637807
Yes
Persian Gulf Sports, Nutrition and Health Research Team, School of Literature and Humanities, Persian Gulf University, Boushehr, Iran