Jorjani Biomedicine Journal
فصلنامه علمی پژوهشی زیست پزشکی جرجانی
Jorjani Biomed J
Medical Sciences
http://goums.ac.ir/jorjanijournal
1
admin
2645-3509
10.52547/jorjanibiomedj
en
jalali
1401
2
1
gregorian
2022
5
1
10
2
online
1
fulltext
en
Therapeutic and Preventive Effects of Aqueous Extracts of Arctium lappa L. and Cichorium intybus L. against Fatty Liver in Rats
علوم پایه پزشکی
Basic Medical Sciences
تحقیقی
Original article
<div style="text-align: justify;"><span style="font-size:14px;"><span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Background and objectives:</span></span></i></b><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> The fatty liver is a reversible form of fat accumulation in the liver cells. The burden of this disease is increasing worldwide. In general, due to the lack of proper treatment and the multiple side effects of existing chemical medicines, researchers have focused on the use of herbal medicines. The aim of this study was to evaluate the therapeutic effects of aqueous extract of Arctium lappa L. (burdock) and Cichorium intybus L. (chicory) on fatty liver in rats fed with high fat diet as respects these plants have been frequently applied in traditional medicine for treatment of the liver-related diseases.<b><i></i></b></span></span></span></span><br>
<span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Material and Methods:</span></span></i></b><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> For this study, 30 Wistar rats weighing 120-220 g were used. The rats were divided into 5 groups and received 125, 250, 500 and 1000 mL/kg of mixture of aqueous extracts of burdock and chicory.<b><i></i></b></span></span></span></span><br>
<span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Results: </span></span></i></b><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Results showed that this aqueous extract reduced the liver macro-vesicles and microvesicles and symptoms of steatosis without any specific liver complications. It was found that 500 and 1000 mL/kg of extract had the most effective therapeutic effect.<b><i></i></b></span></span></span></span><br>
<span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></i></b><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> In conclusion, our study shows that extract of burdock-chicory has the potential to ameliorate fatty liver in rats fed with high-fat diet. This study provides evidence that burdock-chicory extract could be considered as a potential dietary supplement strategy for prevention and treatment of fatty liver. Based on these results, the extract was formulated, and entered the pharmaceutical market.</span></span></span></span></span><span style="font-size:11pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:9.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></div>
Fatty Liver,Aspartate Aminotransferases,Alanine Transaminase,Arctium lappa L. (burdock),Cichorium intybus L. (chicory),
53
61
http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-759-1&slc_lang=en&sid=1
Mohammad
Jafari Shiran
dmjaafari@gmail.com
10031947532846008004
10031947532846008004
No
Researcher of Traditional Medicine and Medicinal Plants, Iranian Academy Center for Education, Culture and Research (ACECR), Medicinal Herbal Center, Ardabil Branch, Ardabil, Iran
Saeed
Naseri
naseri.herbalpharma@gmail.com
10031947532846008005
10031947532846008005
No
Department of Pharmacology-Toxicology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Tahereh
Sadeghian-Rizi
t.sadeghian@ashrafi.ac.ir
10031947532846008006
10031947532846008006
No
Department of Biotechnology, Faculty of Biological Sciences and Technology, Shahid Ashrafi Esfahani University, Isfahan, Iran
Saeed
Khani
saeid.khani@gmail.com
10031947532846008007
10031947532846008007
No
Islamic Medicine Pioneers Company, Ardabil, Iran
Mohammad
Shoormij
denis.jimmy87@gmail.com
10031947532846008008
10031947532846008008
No
Department of Pharmacology-Toxicology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Seyedeh Simin
Dakhilpour
s.dakhilpour@uma.ac.ir
10031947532846008009
10031947532846008009
Yes
Researcher of Traditional Medicine and Medicinal Plants, Iranian Academy Center for Education, Culture and Research (ACECR), Medicinal Herbal Center, Ardabil Branch, Ardabil, Iran