Jorjani Biomedicine Journal
فصلنامه علمی پژوهشی زیست پزشکی جرجانی
Jorjani Biomed J
Medical Sciences
http://goums.ac.ir/jorjanijournal
1
admin
2645-3509
10.52547/jorjanibiomedj
en
jalali
1397
12
1
gregorian
2019
3
1
7
1
online
1
fulltext
en
Reduction of Serum Vitamin B12 Levels among the Female Patients with Breast Cancer (Case Study: Sulaimania city- Iraq)
علوم پایه پزشکی
Basic Medical Sciences
تحقیقی
Original article
<strong><em>Background and objectives:</em></strong> Breast carcinoma is one of the most common malignant diseases among women worldwide. In Iraq there are noticeable elevation in incidence rates and prevalence of advanced stages of breast cancer. Cobalamin (vitamin B12) is essential micronutrient involved in one carbon metabolism and DNA methylation, which affects cancer. All of these may be change in breast cancer. The present work was designed to estimate and compare serum vitamin B12 among female breast cancer patients (60 ones) and healthy control subjects (60 ones) in Sulaimania city.<br>
<strong><em>Methods:</em></strong> This is a case-control study conducted on sixty cases of newly diagnosed women with breast cancer, the control group include sixty healthy women. Serum vitamin B12 levels were estimated by electrochemiluminescence immunoassay (Elecsys) method. Data was analyzed using the software SPSS (Ver. 22) including frequency and percentage for categorical variables. Pearson chi-square test was used for analysis of all categorical variables.<br>
<strong><em>Results: </em></strong>In this study we found that serum vitamin B12 levels were significantly (p=0.01) lower in breast cancer patients as compared to healthy control subject. There was no association between serum vitamin B12 levels with estrogen, progesterone, and HER2 receptor.<br>
<strong><em>Conclusion:</em></strong> Given the results, it can be concluded that serum vitamin B12 is consistently lower among breast cancer patients. There was no association between serum vitamin B12 levels and hormones receptors status, indicating clinical implications for the interpretation of serum vitamin B12 levels. Therefore, it should be taken into consideration by physicians and cancer specialists.<br>
Vitamin B12, Breast Cancer, Sulaimania
39
50
http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-532-1&slc_lang=en&sid=1
Van Abdulqader
Ahmed
vana.ahmed@yahoo.com
10031947532846004314
10031947532846004314
No
Department of Clinical Biochemistry, College of Pharmacy, University of Sulamania, Iraq
Basima Sadiq
Ahmed
basima.ahmed@univsul.edu.iq
10031947532846004315
10031947532846004315
Yes
Department of Clinical Biochemistry, College of Pharmacy, University of Sulamania, Iraq