en علوم مولکولی Molecular Sciences سرمقاله Editorial <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;">In patients with Alzheimer&rsquo;s disease (AD), dysphagia &mdash; a condition affecting most individuals with moderate-to-severe dementia &mdash; novel drug delivery systems (NDDS), including orally disintegrating tablets, transdermal patches, and intranasal sprays, offer a promising approach to improving medication adherence. These delivery modalities enhance compliance, provide more stable drug exposure, reduce swallowing-related complications such as aspiration pneumonia, and facilitate integration with non-pharmacological interventions by eliminating the need for oral swallowing. However, their implementation faces several challenges, including skin sensitivity associated with transdermal systems, nasal irritation with intranasal formulations, regulatory hurdles related to advanced nanocarrier technologies, and the need for supportive health policies and caregiver education to ensure equitable and effective use across diverse care settings.</span></span></div> Drug Delivery Systems, Dementia, Swallowing Problem 1 3 http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-68-7&slc_lang=en&sid=1 Kamyar Khoshnevisan kamyar.khoshnevisan@gmail.com 100319475328460010503 100319475328460010503 No Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Maryam Chehrehgosha chehrehgosha2008@gmail.com 100319475328460010504 100319475328460010504 Yes Department of Surgical Technology, Paramedical School, Golestan University of Medical Sciences, Gorgan, Iran