RT - Journal Article T1 - Review of Phthalates Exposure and Toxicity JF - Jorjani-Biomedicine-Journal YR - 2015 JO - Jorjani-Biomedicine-Journal VO - 3 IS - 2 UR - http://goums.ac.ir/jorjanijournal/article-1-402-en.html SP - 1 EP - 13 K1 - Phthalates K1 - Toxicity K1 - Environment K1 - Medical Devices K1 - Cosmetics K1 - Food K1 - Toy AB - The dialkyl- or alkyl/aryl esters of 1, 2-benzenedicarboxylic acid, which are known as Phthalates, are high-production volume synthetic chemicals and considered as environmental pollutants, due to high production and uses in community, plastics industry and common consuming products. Di-(2-ethylhexyl) phthalate (DEHP) is the most abundant phthalate in the environment. Human exposure with DEHP could be done via different chemical compounds including food packaging, household furnishings, nutritional supplements, cleaning materials and insecticides. Besides, exposure of human with phthalates occurs through different pathways such as direct contact and using Phthalate-containing products, and indirectly through leaching into other products, or general environmental contaminations. Historically, the diet has been considered the major source of phthalate exposure in the general population, but in all sources, pathways, and their relative contributions to human exposures are not well understood. Medical devices are other source of significant exposure in human. Furthermore, cosmetics, personal care products, pharmaceuticals, nutritional supplements, herbal remedies and insecticides, may result in significant but poorly quantified human exposure with this compounds. In the present review article, we tried to discuss about metabolism of phthalates in human, toxicity, monitoring of phthalates in foods, environment, and cosmetic products and then metabolites of phthalates. Finally, evaluation of human exposure through biological control is discussed. LA eng UL http://goums.ac.ir/jorjanijournal/article-1-402-en.html M3 ER -