Volume 10, Issue 2 (5-2022)
Jorjani Biomed J 2022, 10(2): 53-61 |
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Jafari Shiran M, Naseri S, Sadeghian-Rizi T, Khani S, Shoormij M, Dakhilpour S S. Therapeutic and Preventive Effects of Aqueous Extracts of Arctium lappa L. and Cichorium intybus L. against Fatty Liver in Rats. Jorjani Biomed J 2022; 10 (2) :53-61
URL: http://goums.ac.ir/jorjanijournal/article-1-786-en.html
URL: http://goums.ac.ir/jorjanijournal/article-1-786-en.html
Mohammad Jafari Shiran1 
, Saeed Naseri2 , Tahereh Sadeghian-Rizi3 , Saeed Khani4 , Mohammad Shoormij2 , Seyedeh Simin Dakhilpour 5
, Saeed Naseri2 , Tahereh Sadeghian-Rizi3 , Saeed Khani4 , Mohammad Shoormij2 , Seyedeh Simin Dakhilpour 5
1- Researcher of Traditional Medicine and Medicinal Plants, Iranian Academy Center for Education, Culture and Research (ACECR), Medicinal Herbal Center, Ardabil Branch, Ardabil, Iran
2- Department of Pharmacology-Toxicology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
3- Department of Biotechnology, Faculty of Biological Sciences and Technology, Shahid Ashrafi Esfahani University, Isfahan, Iran
4- Islamic Medicine Pioneers Company, Ardabil, Iran
5- Researcher of Traditional Medicine and Medicinal Plants, Iranian Academy Center for Education, Culture and Research (ACECR), Medicinal Herbal Center, Ardabil Branch, Ardabil, Iran ,s.dakhilpour@uma.ac.ir
2- Department of Pharmacology-Toxicology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
3- Department of Biotechnology, Faculty of Biological Sciences and Technology, Shahid Ashrafi Esfahani University, Isfahan, Iran
4- Islamic Medicine Pioneers Company, Ardabil, Iran
5- Researcher of Traditional Medicine and Medicinal Plants, Iranian Academy Center for Education, Culture and Research (ACECR), Medicinal Herbal Center, Ardabil Branch, Ardabil, Iran ,
Abstract: (3927 Views)
Background and objectives: The fatty liver is a reversible form of fat accumulation in the liver cells. The burden of this disease is increasing worldwide. In general, due to the lack of proper treatment and the multiple side effects of existing chemical medicines, researchers have focused on the use of herbal medicines. The aim of this study was to evaluate the therapeutic effects of aqueous extract of Arctium lappa L. (burdock) and Cichorium intybus L. (chicory) on fatty liver in rats fed with high fat diet as respects these plants have been frequently applied in traditional medicine for treatment of the liver-related diseases.
Material and Methods: For this study, 30 Wistar rats weighing 120-220 g were used. The rats were divided into 5 groups and received 125, 250, 500 and 1000 mL/kg of mixture of aqueous extracts of burdock and chicory.
Results: Results showed that this aqueous extract reduced the liver macro-vesicles and microvesicles and symptoms of steatosis without any specific liver complications. It was found that 500 and 1000 mL/kg of extract had the most effective therapeutic effect.
Conclusion: In conclusion, our study shows that extract of burdock-chicory has the potential to ameliorate fatty liver in rats fed with high-fat diet. This study provides evidence that burdock-chicory extract could be considered as a potential dietary supplement strategy for prevention and treatment of fatty liver. Based on these results, the extract was formulated, and entered the pharmaceutical market.
Material and Methods: For this study, 30 Wistar rats weighing 120-220 g were used. The rats were divided into 5 groups and received 125, 250, 500 and 1000 mL/kg of mixture of aqueous extracts of burdock and chicory.
Results: Results showed that this aqueous extract reduced the liver macro-vesicles and microvesicles and symptoms of steatosis without any specific liver complications. It was found that 500 and 1000 mL/kg of extract had the most effective therapeutic effect.
Conclusion: In conclusion, our study shows that extract of burdock-chicory has the potential to ameliorate fatty liver in rats fed with high-fat diet. This study provides evidence that burdock-chicory extract could be considered as a potential dietary supplement strategy for prevention and treatment of fatty liver. Based on these results, the extract was formulated, and entered the pharmaceutical market.
Keywords: Fatty Liver [MeSH], Aspartate Aminotransferases [MeSH], Alanine Transaminase [MeSH], Arctium lappa L. (burdock) , Cichorium intybus L. (chicory)
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The fatty liver is a reversible form of fat accumulation in the liver cells.
The aqueous extract of Arctium lappa L. (burdock) and Cichorium intybus L. (chicory) reduces the liver macro-vesicles and micro-vesicles and symptoms of steatosis without any specific liver complications.
The burdock-chicory extract could be considered a potential dietary supplement strategy for preventing and treating fatty liver.
Type of Article: Original article |
Subject:
Basic Medical Sciences
Received: 2021/01/13 | Accepted: 2022/05/28 | Published: 2022/06/7
Received: 2021/01/13 | Accepted: 2022/05/28 | Published: 2022/06/7
References
1. Söderberg C, Stal P, Askling J, Glaumann H, Lindberg G, Marmur J, et al. Decreased survival of subjects with elevated liver function tests during a 28-year follow-up. Hepatology. 2010;51(2):595-602. [view at publisher] [DOI] [PMID] [Google Scholar]
2. Adams LA, Lymp JF, St Sauver J, Sanderson SO, Lindor KD, Feldstein A, et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology. 2005;129(1):113-21. [DOI] [PMID] [Google Scholar]
3. Jamali R, Khonsari M, Merat S, Khoshnia M, Jafari E, Bahram Kalhori A, et al. Persistent alanine aminotransferase elevation among Iranian general population: prevalence and causes. World Journal of Gastroenterology. 2008;14(18):2867-71. [DOI] [PMID] [PMCID] [Google Scholar]
4. Basaranoglu M, Acbay O, Sonsuz A. A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis. Journal of Hepatology. 1999;31(2):384-92. [view at publisher] [DOI] [Google Scholar]
5. Kiyici M, Gulten M, Gurel S, Nak SG, Dolar E, Savci G, et al. Ursodeoxycholic acid and atorvastatin in the treatment of nonalcoholic steatohepatitis. Canadian Journal of Gastroenterology. 2003;17(12):713-8. [DOI] [PMID] [Google Scholar]
6. Lindor KD, Kowdley KV, Heathcote EJ, Harrison ME, Jorgensen R, Angulo P, et al. Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: Results of a randomized trial. Hepatology.e 2004;39(3):770-8. [DOI] [PMID] [Google Scholar]
7. Marchesini G, Marzocchi R, Agostini F, Bugianesi E. Nonalcoholic fatty liver disease and the metabolic syndrome. Current Opinion in Lipidology. 2005;16(4):421-7. [view at publisher] [DOI] [PMID] [Google Scholar]
8. Park H, Hwang Y, Kim DG, Jeon J, Ma JY. Hepatoprotective effect of herb formula KIOM2012H against nonalcoholic fatty liver disease. Nutrients. 2015;7(4):2440-55. [DOI] [PMID] [PMCID] [Google Scholar]
9. Bi Y, Tugume AK, Valkonen JPT. Small-RNA deep sequencing reveals Arctium tomentosum as a natural host of Alstroemeria virus X and a New Putative Emaravirus. PLoS One. 2012;7(8): e42758. [DOI] [PMID] [PMCID] [Google Scholar]
10. Li J, S. Ding and X. Ding. Optimization of the ultrasonically assisted assisted extraction of polysaccharides from Zizyphus jujuba cv. Jinsixiaozao. Journal of Food Engineering. 2007;80 (1): 176-83. [DOI] [Google Scholar]
11. Awale S, Lu J, Kalauni SK, Kurashima Y, Tezuka Y, Kadota S, et al. Identification of Arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation. Cancer Research. 2006;66 (3):1751 -7. [DOI] [PMID] [Google Scholar]
12. Kim BH, Hong SS, Kwon SW, Lee HY, Sung H, Lee IJ, et al. Diarctigenin, a lignan constituent from Arctium lappa, down-regulated zymosan-induced transcription of inflammatory genes through suppression of DNA binding ability of Nuclear Factor-kappa B in macrophages. Journal of Pharmacology and Experimental Therapeutics. 2008;327(2):393-401. [view at publisher] [DOI] [PMID] [Google Scholar]
13. Suzuki S, Umezawa T, Shimada M. Stereochemical diversity in lignin biosynthesis of Arctium lappa L. Bioscience, Biotechnology, and Biochemistry. 2002;66 (6):1262-9. [view at publisher] [DOI] [PMID] [Google Scholar]
14. Cha JY, Park CK, Cho YS. Hepatoprotective effect of chicory (Chicorium intybus) root extract against orotic acid-induced fatty liver in rats. Food Science Biotechnology. 2010;19:865-71. [DOI] [Google Scholar]
15. Faraji S, Daneghian S, Alizadeh M. Effects of chicory (Cichorium intybus L.) on nonalcoholic fatty liver disease. Traditional Medicine Research. 2020; 5(6):476-86. [DOI] [Google Scholar]
16. Ghaffari A, Rafraf M, Navekar R, Sepehri B , Asghari-Jafarabadi M , Ghavami SM. Turmeric and chicory seed have beneficial effects on obesity markers and lipid profile in non-alcoholic fatty liver disease (NAFLD). International Journal for Vitamin and Nutrition Research. 2019;89:293-302. [view at publisher] [DOI] [PMID] [Google Scholar]
17. Lin S, C, Lin C, H, Lin C, C, Lin Y, H, Chen C, F, Chen I, -C, Wang L, -Y: Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride. Journal of Biomedical Science. 2002;9:401-9. [DOI] [PMID] [Google Scholar]
18. Hou B, Wang W, Gao H, Cai S, Wang C. Effects of aqueous extract of Arctium lappa L. roots on serum lipid metabolism. The Journal of international medical research. 2018;46(1):158-67. [DOI] [PMID] [PMCID] [Google Scholar]
19. Koelzer J, Pereira DA, Dalmarco JB, Pizzolattib MG, Frödea TS. Evaluation of the anti-inflammatory efficacy of Lotus corniculatus. Journal of Food Chemistry. 2009;117(3):444-50. [DOI] [Google Scholar]
20. Zou Y, Li J, Lu C, Wang J, Ge J, Huang Y, et al. High- fat emulsion-induced rat model of nonalcoholic steatohepatitis. Life Science. 2006;79(11):1100-7. [DOI] [PMID] [Google Scholar]
21. Haznedaroglu MZ, Zeybek U. HPLC Determination of chicoric acid in leaves of Posidonia oceanica. Pharmaceutical Biology. 2007;45(10):745-8. [DOI] [Google Scholar]
22. Assy N, Kaita K, Mymin D, Levy C, Rosser B, Minuk G. Fatty infiltration of liver in hyperlipidemic patients. Digestive Diseases and Sciences. 2000;45(10):1929-34. [DOI] [PMID] [Google Scholar]
23. Kametani T, Koshida H, Nagaoka T, Miyakoshi H. Hypertriglyceridemia is an independent risk factor for development of impaired fasting glucose and diabetes mellitus: a 9-year longitudinal study in Japanese. Internal Medicine. 2002;41(7):516-21. [DOI] [PMID] [Google Scholar]
24. Walldius G, Aastveit A, Jungner I. Hypercholesterolemia and hypertriglyceridemia greatest cardiac risk in subjects with high apoB/apoA-I levels. International Congress Series. 2004;1262:203-6. [DOI] [Google Scholar]
25. Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. Journal of Clinical Investigation. 2005;115(5):1343-51. [DOI] [PMID] [PMCID] [Google Scholar]
26. Chidambarama J, Venkatraman CA. Cissus quadrangularis stem alleviates insulin resistance, oxidative injury and fatty liver disease in rats fed high fat plus fructose diet. Food and Chemical Toxicology. 2010;48(8-9):2021-9. [DOI] [PMID] [Google Scholar]
27. Angulo P. Non alcoholic fatty liver disease. The New England Journal of Medicine. 2002;18(346):1221-31. [view at publisher] [DOI] [PMID] [Google Scholar]
28. Wang JQ, Li J, Zou YH, Cheng WM, Lu C, Zhang L, et al. Preventive effects of total flavonoids of Litsea coreana leave on hepatic steatosis in rats fed with high fat diet. Journal of Ethnopharmacology. 2009;121(1):54-60. [DOI] [PMID] [Google Scholar]
29. Al-Wabel NA, Mousa HM, Omer OH, Abdel-Salam AM. Biological evaluation of aqueous herbal extracts and stirred yoghurt filtrate mixture against alloxan-induced oxidative stress and diabetes in rats. International Journal of Pharmacology. 2008;4(2): 135-9. [DOI] [Google Scholar]
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