Volume 7, Issue 3 (9-2019)
Jorjani Biomed J 2019, 7(3): 45-55 |
Back to browse issues page
1- Department of Oral Medicine, Tabriz University of Medical Sciences, Tabriz, Iran , paria@motahari.com
2- Research center for evidence based medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3- Department of Oral Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2- Research center for evidence based medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3- Department of Oral Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract: (5515 Views)
Background and objectives: Most studies have identified interferon-gamma (IFN-γ) as a key role in the pathogenesis of oral lichen planus (OLP). Recent studies have also shown a link between IFN-γ (+874 A/T) gene polymorphism and OLP. The purpose of the present meta-analysis is to investigate the relationship between IFN-γ (+874 A/T) gene polymorphism and susceptibility to OLP.
Methods: A systematic search of resources to investigate the association between IFN-γ and OLP from Google scholar, PubMed, Embase, Cochrane, Scopus, Proquest, Ovid and Web of science (from 2000 to April 2019) completed. Two individuals independently assessed the quality of the articles. Endnote X5 resource management software was used to organize, study titles and abstracts as well as identify duplicates. A random effect model was also used to perform the meta-analysis.
Results: Four IFN-γ (+874 A/T) polymorphism studies with 297 patients in the case group and 621 healthy controls in the 4 different countries were included. After meta-analysis, a significant association was found between IFN-γ polymorphism (+874 A/T) and OLP. (T vs A: odds ratio (OR) = 1.62; 95% CI = 1.28-2.04; TT vs AA: OR = 2.67; 95% CI = 1.6- 4.45; AT vs AA: OR = 1.56; 95% CI = 1.6- 4.45; TT vs AT + AA: OR = 1.73; 95% CI = 1.13-2.64; AT + TT vs AA: OR = 1.75; 95% CI = 1.28-2.43)
Conclusion: Based on this meta-analysis, there was a positive relationship between IFN-γ (+874 A/T) gene polymorphism and the risk of OLP. The findings showed that increasing TT genotypes significantly increased susceptibility to OLP in comparison with other genotypes.
Methods: A systematic search of resources to investigate the association between IFN-γ and OLP from Google scholar, PubMed, Embase, Cochrane, Scopus, Proquest, Ovid and Web of science (from 2000 to April 2019) completed. Two individuals independently assessed the quality of the articles. Endnote X5 resource management software was used to organize, study titles and abstracts as well as identify duplicates. A random effect model was also used to perform the meta-analysis.
Results: Four IFN-γ (+874 A/T) polymorphism studies with 297 patients in the case group and 621 healthy controls in the 4 different countries were included. After meta-analysis, a significant association was found between IFN-γ polymorphism (+874 A/T) and OLP. (T vs A: odds ratio (OR) = 1.62; 95% CI = 1.28-2.04; TT vs AA: OR = 2.67; 95% CI = 1.6- 4.45; AT vs AA: OR = 1.56; 95% CI = 1.6- 4.45; TT vs AT + AA: OR = 1.73; 95% CI = 1.13-2.64; AT + TT vs AA: OR = 1.75; 95% CI = 1.28-2.43)
Conclusion: Based on this meta-analysis, there was a positive relationship between IFN-γ (+874 A/T) gene polymorphism and the risk of OLP. The findings showed that increasing TT genotypes significantly increased susceptibility to OLP in comparison with other genotypes.
Type of Article: Original article |
Subject:
General medicine
Received: 2019/03/15 | Accepted: 2019/08/15 | Published: 2019/09/1
Received: 2019/03/15 | Accepted: 2019/08/15 | Published: 2019/09/1
References
1. Tao X, Huang Y, Li R, Qing R, Ma L, Rhodus NL, et al. Assessment of local angiogenesis and vascular endothelial growth factor in the patients with atrophic-erosive and reticular oral lichen planus. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2007;103(5):661-9. [DOI] [Google Scholar]
2. Liu G-X, Sun J-T, Yang M-X, Qi X-M, Shao Q-Q, Xie Q, et al. OPN promotes survival of activated T cells by up-regulating CD44 in patients with oral lichen planus. Clinical Immunology. 2011;138(3):291-8. [DOI] [Google Scholar]
3. Sugerman P, Savage N, Walsh L, Zhao Z, Zhou X, Khan A, et al. The pathogenesis of oral lichen planus. Critical Reviews in Oral Biology & Medicine. 2002;13(4):350-65. [DOI] [Google Scholar]
4. Zhou ZT, Wei BJ, Shi P. Osteopontin expression in oral lichen planus. Journal of oral pathology & medicine. 2008;37(2):94-8. [DOI] [Google Scholar]
5. Neurath MF, Finotto S, Glimcher LH. The role of Th1/Th2 polarization in mucosal immunity. Nature medicine. 2002;8(6):567. [DOI] [Google Scholar]
6. Gray PW, Goeddel DV. Structure of the human immune interferon gene. Nature. 1982;298(5877):859. [DOI] [Google Scholar]
7. Schoenborn JR, Wilson CB. Regulation of interferon‐γ during innate and adaptive immune responses. Advances in immunology. 2007;96:41-101. [DOI] [Google Scholar]
8. Hamzaoui K, Hamzaoui A, Guemira F, Bessioud M, Hamza MH, Ayed K. Cytokine profile in Behçet's disease patients. Scandinavian journal of rheumatology. 2002;31(4):205-10. [DOI] [Google Scholar]
9. Danielsson K, Ebrahimi M, Wahlin Y-B, Nylander K, Boldrup L. Increased levels of COX‐2 in oral lichen planus supports an autoimmune cause of the disease. Journal of the European Academy of Dermatology and Venereology. 2012;26(11):1415-9. [DOI] [Google Scholar]
10. Pravica V, Perrey C, Stevens A, Lee J-H, Hutchinson IV. A single nucleotide polymorphism in the first intron of the human IFN-γ gene:: Absolute correlation with a polymorphic CA microsatellite marker of high IFN-γ production. Human immunology. 2000;61(9):863-6. [DOI] [Google Scholar]
11. Reichert S, Machulla HK, Klapproth J, Zimmermann U, Reichert Y, Gläser C, et al. Interferon‐gamma and interleukin‐12 gene polymorphisms and their relation to aggressive and chronic periodontitis and key periodontal pathogens. Journal of periodontology. 2008;79(8):1434-43. [DOI] [Google Scholar]
12. Bai J, Lin M, Zeng X, Zhang Y, Wang Z, Shen J, et al. Association of polymorphisms in the human IFN-γ and IL-4 gene with oral lichen planus: a study in an ethnic Chinese cohort. journal of interferon & cytokine research. 2008;28(6):351-8. [DOI] [Google Scholar]
13. Carrozzo M, Dametto E, Fasano ME, Arduino P, Broccoletti R, Vezza D, et al. Tumor necrosis factor-α and interferon-γ polymorphisms contribute to susceptibility to oral lichen planus. Journal of Investigative Dermatology. 2004;122(1):87-94. [DOI] [Google Scholar]
14. Kimkong I, Nakkuntod J, Sodsai P, Hirankarn N, Kitkumthorn N. Association of interferon-gamma gene polymorphisms with susceptibility to oral lichen planus in the Thai population. Archives of oral biology. 2012;57(5):491-4. [DOI] [Google Scholar]
15. Azab NA, El Salam LA, Ahmed E, El Sharkawy M, ElSharkawy A, El Asheiry SG. Interferon gamma and interleukin 8 gene polymorphisms in patients with hepatitis C virus related oral lichen planus. Archives of oral biology. 2018;96:189-94. [DOI] [Google Scholar]
16. Lee YH, Bae SC. Association between interferon-γ+ 874 T/A polymorphism and susceptibility to autoimmune diseases: a meta-analysis. Lupus. 2016;25(7):710-8. [DOI] [Google Scholar]
17. Moher D, Liberati A, Tetzlaff J, Altman DG. PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009;6:e1000097. [DOI] [Google Scholar]
18. Munn Z, Moola S, Lisy K, Riitano D. The Joanna Briggs Institute Reviewers' Manual 2014. The systematic review of prevalence and incidence data. Adelaide, SA: The Joanna Briggs Institute 2014. [Google Scholar]
19. Camargo MC, Mera R, Correa P, Peek RM, Fontham ET, Goodman KJ, et al. Interleukin-1β and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis. Cancer Epidemiology and Prevention Biomarkers. 2006;15(9):1674-87. [DOI] [Google Scholar]
20. Guo J, Jin M, Zhang M, Chen K. A genetic variant in miR-196a2 increased digestive system cancer risks: a meta-analysis of 15 case-control studies. PloS one. 2012;7(1):e30585. [DOI] [Google Scholar]
21. Heidari Z, Mahmoudzadeh-Sagheb H, Hashemi M, Ansarimoghaddam S, Moudi B, Sheibak N. Association between IFN-γ. International journal of dentistry. 2015;2015. [DOI] [Google Scholar]
22. Ianni M, Bruzzesi G, Pugliese D, Porcellini E, Carbone I, Schiavone A, et al. Variations in inflammatory genes are associated with periodontitis. Immunity & Ageing. 2013;10(1):39. [DOI] [Google Scholar]
23. Loo WT, Fan C-b, Bai L-j, Yue Y, Dou Y-d, Wang M, et al., editors. Gene polymorphism and protein of human pro-and anti-inflammatory cytokines in Chinese healthy subjects and chronic periodontitis patients. Journal of translational medicine; 2012: BioMed Central. [DOI] [Google Scholar]
24. Al-Mohaya MAM, Al-Otaibi L, Al-Harthi F, Al Bakr E, Arfin M, Al-Asmari A. Association of genetic polymorphisms in interferon-γ, interleukin-6 and transforming growth factor-β1 gene with oral lichen planus susceptibility. BMC oral health. 2016;16(1):76. [DOI] [Google Scholar]
25. De Albuquerque A, Rocha L, de Morais Batista A, Teixeira A, Dos Santos D, Nogueira N. Association of polymorphism+ 874 A/T of interferon-γ and susceptibility to the development of tuberculosis: meta-analysis. European Journal of Clinical Microbiology & Infectious Diseases. 2012;31(11):2887-95. [DOI] [Google Scholar]
26. Holla LI, Hrdlickova B, Linhartova P, Fassmann A. Interferon-γ+ 874A/T polymorphism in relation to generalized chronic periodontitis and the presence of periodontopathic bacteria. archives of oral biology. 2011;56(2):153-8. [DOI] [Google Scholar]
27. Liu N, Song Y, Shi W. IFN-γ+ 874 T/A polymorphisms contributes to cervical cancer susceptibility: a meta-analysis. International journal of clinical and experimental medicine. 2015;8(3):4008. [Google Scholar]
28. Silva G, Naveca F, Ramasawmy R, Boechat A. Association between the IFNG+ 874A/T gene polymorphism and leprosy resistance: a meta-analysis. Cytokine. 2014;65(2):130-3. [DOI] [Google Scholar]
29. Sun Y, Lu Y, Pen Q, Li T, Xie L, Deng Y, et al. Interferon gamma+ 874 T/A polymorphism increases the risk of cervical cancer: evidence from a meta-analysis. Tumor Biology. 2015;36(6):4555-64. [DOI] [Google Scholar]
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |